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[Pediatrics]
Leonid Klimov; Lilit Аlaverdyan; Natalia Verisokina; Victoria Kuryaninova; Roza Atanesyan; Tatiana Zheleznyakova; Elena Popova; Dmitry Bobryshev;
The paper presents data of clinical-anthropometric and laboratory examination of newborns from mothers with impaired glucose metabolism.
In the group of children born from mothers with GDM, the mass and length of the newborns are significantly higher than in the control group (p<0.01) and (p<0.05), respectively. The level of leptin in the group of newborns born from mothers with type 1 DM is 2.7 times (p<0.01), and IGF-1 is 1.9 times higher (p<0.001) than in the comparison group. In the group of children whose mothers had GDM, leptin values were 2.1 times (p<0.05), and IGF-1 was 1.5 times higher (p<0.01) than in the control group; in patients whose mothers had GDM on the background of obesity, the leptin level was 3.6 times (p<0.001), and the free leptin index was 5.2 times (p<0.001) higher than in mothers of healthy children.
In children from mothers with type 1 DM a direct correlation was established between the level of leptin and weight (r=0.53, p<0.01) and length (r=0.44, p<0.05), and in children born from mothers with GDM – between IGF-1 and weight (r=0.86, p<0.001), and length (r=0.83, p<0.001), as well as between IGF-1 and head circumference (r=0.69 (p<0.01). In
children born from mothers with a combination of GDM and obesity, the correlation dependence was traced between IGF-1 and weight (r=0.60, p<0.01), and also between IGF-1 and growth (r=0.57, p<0.05).
Thus, antenatal hormonal-metabolic patterns against the background of glucose metabolism disorders in mothers have a pronounced effect not only on the course of pregnancy and the state of the newborn, but also program the rates of physical development in early childhood.
References:
1. Neumann Je. G., Shitkovskaya E. P., Ilyenkova N. A., Chikunov V. V., Prokoptseva N. L. Features of the neonatal period in children born to mothers with diabetes. Sibirskoe medicinskoe obozrenie. – Siberian medical review. 2014;4:75-78. (In Russ.).
2. Kim S. Y., Sharma A. J., Sappenfield W., Wilson H. G., Salihu H. M. Association of maternal body mass index, excessive weight gain, and gestational diabetes mellitus with larde-for-gestational-age births. Obstet. Gynecol. 2014;123(4):737-744.
3. Bozkurt L., Gobl C.S., Pfligl L., Leitner K., Bancher-Todesca D., Luger A., Baumgartner-Parzer S., Pacini G., Kautzky-Willer A. Pathophysiological characteristics and effects of obesity in women with early and late manifestation of gestational diabetes diagnosed by the International Association of Diabetes and Pregnancy Study Groups criteria. J. Clin. Endocrinol. Metab. 2015;100(3):1113- 1120. https://doi.org/10.1210/jc.2014-4055
4. Mikhalev E. V., Shanina O. M., Saprina T. V. Hormonal, electrolyte disorders and hemostatic features in full-term infants from mothers with gestational diabetes. Saharnyj diabet. – Diabetes. 2015;1:78-86. (In Russ.).
5. Dedov I. I., Krasnopolsky V. I., Dry G. T. Russian national consensus «Gestational diabetes: diagnosis, treatment, postpartum monitoring». Saharnyj diabet. – Diabetes. 2012;4:4-10. (In Russ.).
6. Mpondo B. C., Ernest А., Dee Н. Е. Gestational diabetes mellitus: challenges in diagnosis and management. Diabetes Metab. Disord. 2015;12:14-42. https://doi.org/10.1186/s40200-015-0169-7
7. Nikitina I. L., Konoplya I. S., Polyanskaya A. A., Liskina A. S., Popova P. V. Characteristics of physical and psychomotor development of children born to mothers with gestational diabetes mellitus. Medicinskij sovet. – Medical council. 2017;9:14-20. (In Russ.).
8. Litvinenko I. A., Karpova E. V., Kotaysh G. A., Bratchikova T. V., Tabatadze N. T., Sheshko P. L., Gondarenko A. S. Prediction of perinatal outcomes in pregnant women with gestational diabetes. Vestnik RUDN. Seriya: Medicina. – Bulletin RUDN. Series: Medicine. 2011;6:306-315. (In Russ.).
9. Bush N. C., Chandler-Laney P. C., Rouse D. J., Granger W. M., Oster R. A., Gower B. A. Higher maternal gestational glucose concentration is associated with lower offspring insulin sensitivity and altered beta-cell function. J. Clin. Endocrinol. Metab. 2011;96(5):803-809. https://doi.org/10.1210/jc.2010-2902
10. Esakoff T. F., Cheng Y. W., Sparks T. N., Caughey A. B. The association between birthweight 4000 g or greater and perinatal outcomes in patients with and without gestational diabetes mellitus. Amer. J Obstet. Gynecol. 2009;200(6):672-674. https://doi.org/10.1016/j.ajog.2009.02.035
11. Zhuk T. V., Yavorskaya S. D., Vostrikov V. V. Obesity, reproduction and oxidative stress. Ozhirenie i metabolism. – Obesity and metabolism. 2017;14(4):16-22. (In Russ.). http://doi.org/10.14341/omet2017416-22
12. Karelina O. B., Artymuk N. V. Features of leptin content in pregnant women with obesity and their newborns. Fundamental’naya i klinicheskaya medicina. – Fundamental and clinical medicine. 2016;2(3):21-27. (In Russ.). http://doi.org/10.23946/2500-0764-2017-2- 3-21-27
13. Pan H., Guo J., Su Z. Advances in understanding the interrelations between leptin resistance and obesity. Physiol. Behav. 2014;(130):157-169. https://doi.org/10.1016/j. physbeh.2014.04.003
14. Münzberg H., Morrison C. D. Structure, production and signaling of leptin. Metabolism. 2015;64(1):13-23. https://doi.org/10.1016/j.metabol.2014.09.010
15. Смирнова Е. Н., Шулькина С. Г. Содержание лептина, растворимых рецепторов лептина и индекса свободного лептина у больных с метаболическим синдромом. Ожирение и метаболизм. 2017;1:30-34. [Smirnova E. N., Shulkina S. G. Content of leptin, soluble leptin receptors and free leptin index in patients with metabolic syndrome. Ozhirenie i metabolism. – Obesity and metabolism. 2017;1:30-34. (In Russ.)]. http:// doi.org/10.14341/omet2017130-34
16. Patenaude J., Lacerte G., Lacroix M., Guillemette L., Allard C., Doyon M., Battista M. C., Moreau J., Mеnard J., Ardilouze J. L., Perron P., Hivert M. F. Associations of maternal leptin with neonatal adiposity differ according to pregravid weight. Neonatology. 2017;111(4):344-352. https://doi.org/10.1159/000454756
17. Lacroix M., Battista M. C., Doyon M., Moreau J., Patenaude J., Guilllemente L., Menard J., Ardilouze J. L., Perron P., Hivert M. F. Higher maternal leptin levels at second trimester are associated with subsequent greater gestational weight gain in the late pregnancy. BMC Pregnancy Childbirth. 2016;16:62. https://doi.org/10.1186/s12884-016-0842-y
18. Marino-Ortega L. A., Molina-Bello A., Polanco-García J. C., Muñoz-Valle J. F., Salgado-Bernabé A. B., Guzmán- Guzmán I. P., Parra-Rojas I. Correlation of leptin and soluble leptin receptor levels with anthropometric parameters in mother-newborn pairs. Int. J. Clin. Exp. Med. 2015;8(7):11260-11267.
19. Borodich T. C. Modifiable risk factors for obesity and overweight in early childhood. Ozhirenie i metabolism. – Obesity and metabolism. 2015;12(2):51. (In Russ.). http://doi.org/10.14341/omet2015251
Keywords: leptin, IGF-1, ghrelin, endocrinopathy, diabetic fetopathy