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Clinical -anthropometric and laboratory parameters of newborns from mothers with impaired glucose metabolism

[Pediatrics]
Leonid Klimov; Lilit Аlaverdyan; Natalia Verisokina; Victoria Kuryaninova; Roza Atanesyan; Tatiana Zheleznyakova; Elena Popova; Dmitry Bobryshev;

The paper presents data of clinical-anthropometric and laboratory examination of newborns from mothers with impaired glucose metabolism.

In the group of children born from mothers with GDM, the mass and length of the newborns are significantly higher than in the control group (p<0.01) and (p<0.05), respectively. The level of leptin in the group of newborns born from mothers with type 1 DM is 2.7 times (p<0.01), and IGF-1 is 1.9 times higher (p<0.001) than in the comparison group. In the group of children whose mothers had GDM, leptin values were 2.1 times (p<0.05), and IGF-1 was 1.5 times higher (p<0.01) than in the control group; in patients whose mothers had GDM on the background of obesity, the leptin level was 3.6 times (p<0.001), and the free leptin index was 5.2 times (p<0.001) higher than in mothers of healthy children.
In children from mothers with type 1 DM a direct correlation was established between the level of leptin and weight (r=0.53, p<0.01) and length (r=0.44, p<0.05), and in children born from mothers with GDM – between IGF-1 and weight (r=0.86, p<0.001), and length (r=0.83, p<0.001), as well as between IGF-1 and head circumference (r=0.69 (p<0.01). In
children born from mothers with a combination of GDM and obesity, the correlation dependence was traced between IGF-1 and weight (r=0.60, p<0.01), and also between IGF-1 and growth (r=0.57, p<0.05).

Thus, antenatal hormonal-metabolic patterns against the background of glucose metabolism disorders in mothers have a pronounced effect not only on the course of pregnancy and the state of the newborn, but also program the rates of physical development in early childhood.

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Keywords: leptin, IGF-1, ghrelin, endocrinopathy, diabetic fetopathy


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