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ISSN 2073-8137
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Irritable bowel syndrome: pathophysiological role of intestinal dysbiosis and possibilities of its modulation

[Review]
Kubanich Aitbaev; Ilhom Murkamilov; Viktor Fomin; Furkat Yusupov; Nodira Redjapova; Zafarbek Raimzhanov; Ziyabidin Aidarov;

The review presents data on the relationship of intestinal dysbiosis with irritable bowel syndrome (IBS) and the possibility of modulation of the intestinal microbiota (MB) in IBS therapy. It is shown that imbalance of MB caused by the influence of diet, antibiotics or other exogenous factors leads to gastrointestinal disorders, in particular, to the development of IBS. The data are presented that the modulation of MB with the help of prebiotics, antibiotics, probiotics and fecal microbiota transplantation has a positive therapeutic effect in patients with IBS.

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Keywords: irritable bowel syndrome, gut microbiota, prebiotics, probiotics, antibiotics, fecal microbiota transplantation


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Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy