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ISSN 2073-8137

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Clinical -diagnostic value of conducting pharmacological tests for the study of endothelial function in chronic heart failure

[Clinical Pharmacology] [Pharmacology]
Ekaterina Polunina; Lyudmila Voronina; Olga Polunina; Irina Sevostyanova;

To study the clinical diagnostic value of conducting pharmacological tests for the study of endothelial function in patients with chronic heart failure (CHF) of ischemic genesis with preserved left ventricular ejection fraction (PLVEF) depending on the stage of the disease. We examined 148 patients with chronic CHF of ischemic genesis with PLVEF by laser Doppler flowmetry of each patient, complemented by ionophoretic tests with acetylcholine and sodium nitroprusside. In response to the introduction of an endothelium-independent vasodilator in patients with CHF with PLVEF, a slowing of the reaction of microvessels, a decrease in the time of preservation of vasodilation and its manifestation with an increase in the stage of CHF from I to IIA was observed. In response to the introduction of endothelium-dependent vasodilator in patients with CHF with and PLVEF an increase in time of development of vasodilation with increase stage of CHF to IIB–III was revealed, this reflected a general tendency of decreasing reactivity of the microvessels with the progression of heart failure. In patients with CHF with PLVEF, a general tendency to decrease the duration and severity of vasodilation with an increase in CHF stage was found.


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Keywords: chronic heart failure, left ventricular ejection fraction, laser Doppler flowmetry, vasodilatation

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy