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ISSN 2073-8137
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Influence of drinking diet with low content of deuterium on the indicators of the estrous cycle and the adaptive capabilities of the organism in female rats in the presenile age

[Experimental medicine]
Alla Shikhliarova; Galina Zhukova; Oleg Kit; Tatiana Kurkina; Elena Shirnina; Tatiana Protasova; Anna Elkina; Michael Baryshev;

It was established the presence of geroprotector effect in water with a modified isotope D/H composition with reduced deuterium concentration (–704 ‰). It appears to change the duration of individual stages of the estrous cycle (dioestrus, prooestrus and meta oestrus) and the ratio of the length of the stages of the sexual cycle in general, white mongrel female rats presenile age (20–22 months) and the approximation of these parameters to the same values in young animals. Herewith it shown the connection geroprotector effect of water with a modified isotope D/H composition with reduced deuterium concentration with anti-stress effect of this factor, that manifested in the development of persistent anti-stress reactions, that are characterized by the highest relative number of lymphocytes in the blood (adaptive reaction of the calm activation and adaptive reaction of the increased activation), also in the expressed signs of improvement of the coat. The efficiency of using of water with a modified isotope D/H structure with reduced deuterium concentration allows to consider the nutritional factor as a promising means of holistic geriatrics in presenile period of ontogenesis.

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Keywords: deuterium, rats-females presenile age, estrous cycle, anti-stress adaptive reaction, geroprotective effect


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