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https://doi.org/10.14300/mnnc.2018.13023

Biochemical markers of osteogenesis and inflammation in the blood serum in xenoim plantation

[Experimental medicine]
Aleksandr Nakoskin; Mikhail Kovin’ka; Irina Talashova; Natalia Tushina; Svetlana Luneva;

Biochemical indices of bone remodeling in the blood serum were studied in the case of xenoimplantation of extracellular matrix into bone defects in rabbits. The material obtained by the original technology from the bone tissue of bulls, horses, rabbits was used as xenoimplants. The possibility of using complex xenon materials based on bone tissue and antibiotic was also studied. There were no significant differences in the response of various tissues and organs with xenoimplantation and alloimplantation. It was found that with xenoimplantation of a complex material on the basis of bone tissue and an antibiotic, a pronounced inflammatory reaction to implantation is observed.

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Keywords: xenograft, alkaline phosphatase, acid phosphatase, C-reactive protein, protein fractions, substitution of bone defects