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https://doi.org/10.14300/mnnc.2018.13001

Ethylmethylhydroxypyridine malate effect on hepar metabolic function in patients with different functional classes of chronic heart failure

[Original research] [Internal diseases]
Vladimir Kukes; Evgeniya Shih; Anna Zhestovskaia; Ludmila Pavlova; Olga Goroshko;

Activity of CYP3A4 cytochrome Р450 was examined in 90 patients with I–III functional classes of chronic heart failure (CHF) before and after the seven-day intravenous administration of Ethylmethylhydroxypyryridine malate (Ethoxidol) 100 mg/day. There was a statistically significant increase of CYP3A4 cytochrome Р450 activity evaluated by
urinary 6-β-hydroxycortisol/cortisol ratio in patients with I, II and III functional classes of CHF after seven day intravenous administration of 100 mg/day Ethylmethylhydroxypyryridine malate.

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Keywords: chronic heart failure, ethylmethylhydroxypyryridine malate, CYP3A4 of cytochrome Р450 activity