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https://doi.org/10.14300/mnnc.2017.12125

Peculiarities of pathological changes in the mucose membrane of the gastroduodenal zone in dependence on the etiological factors of development of acute gastropathies

[Morphology]
Ismail Miziev; Angelica Musukaeva; Rustam Akhkubekov; Askar Zhigunov; Liliya El’garova; Madina Marzhokhova; Boris Belimgotov;

The purpose of the study was morphological and histochemical study of the pathogenesis of acute ulceration of the stomach and duodenum with various etiological factors of acute gastropathy. The study is based on clinical and morphological analysis of the examination and treatment of 452 patients who had been treated for acute ulceration of the gastroduodenal zone of digestive tract. As a general morphohistological characteristic of the state of the gastric mucosa of these patients, it was noted: 1) the presence of acute ulcers or acute erosion; 2) violation of microcirculation; 3) a decrease of density and fluorescence of adrenergic nerve fibers and increase of acetylcholinesterase activity
in the cholinergic nerve fibers; 4) the presence of Helicobacter pylori; 5) the presence of chronic inflammation; 6) violation of cellular regeneration.

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Keywords: acute ulcers, acetylcholine, vegetative innervation, acid production, Helicobacter pylori