of the North Caucasus
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Effect of pinealectomy and melatonin on rat learning in the modified water maze
[Experimental medicine]
Eduard Arushanyan; Karen Ovanesov;
The removal of the epiphysis makes it difficult to train the avoidance response in rats in Morris’ modified water maze. Animals make more mistakes and spend more time searching for a rescue site. Epiphyseal hormone melatonin (0.1 mg / kg) with chronic administration facilitated the acquisition of an avoidance skill. It is assumed that melatonin can act as a natural nootropic agent that improves the cognitive activity of the brain.
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Keywords: pineal gland, melatonin, learning, water maze
Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy