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Prognostic value of vascular endothelial growth factor in patients with mitral valve prolapse and connective tissue dysplasia

[Internal diseases]
Tamara Zangelova; Natalia Gladkikh; Alexandr Yagoda;

The aim was to evaluate the predictive value of vascular endothelial growth factor type A (VEGF-A) and its receptors – VEGF-R1 и VEGF-R2 – for cardiovascular events in patients with mitral valve prolapse and connective tissue dysplasia.
83 patients (61 men, 22 female, aged 21.93±4.22 years) with primary MVP were enrolled in the study. Follow-up period was 3 years. Circulated VEGF-A, VEGF-R1 и VEGF-R2 levels were determined once at baseline. All cardiovascular clinical and instrumental outcomes during 3 years of observation considered as endpoints.
At baseline VEGF-А ≤197.3 pg/ml, VEGF-A/VEGF-R1 ≤ 0.65, VEGF-A/VEGF-R2 ≤ 0.007 were associated with the increase of mitral valve prolapse degree, left ventricle myocardium mass index, and also with clinically significant arrhythmias.
Complex of indicators (reduced VEGF-A, VEGF-A/VEGF-R1, VEGF-A/VEGF-R2) is an independent predictor of structural and functional changes of cardiovascular system in young patients with mitral valve prolapse.

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Keywords: mitral valve prolapse, connective tissue dysplasia, vascular endothelial growth factor, predicted value


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