Site search
Correspondence address
310 Mira Street, Stavropol, Russia, 355017
Tel
+7 865 2352511, +7 865 2353229.
E-mail
medvestnik@stgmu.ru
The journal is included into The list of leading scientific periodicals.
The journal is included into VINITI database and is registered in Electronic scientific library.
The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.
[Pediatrics]
Leonid Klimov; Irina Zakharova; Stanislav Maltcev; Svetlana Malyavskaya; Anastasiya Yagupova; Svetlana Dolbnya; Аnna Kasyanova; Victoria Kuryaninova; Dmitry Bobryshev;
The paper presents an analysis of the relationship between the duration of cholecalciferol supplementation at different doses and the 25(ОН)D concentration in infants during their first year of life. We evaluated 496 infants aged 1 month to 12 months who were divided into four groups depending on the duration of vitamin D supplementation: up to 8 weeks, 8–15 weeks, 16–24 weeks, and over 24 weeks.
The results obtained in this study demonstrate rather low vitamin D levels in infants, both breastfed and formula-fed. It was demonstrated that use of higher (1000–1500 IU/day) prophylactic doses of vitamin D than the conventionally used 500 IU/day dose is justified if the aim is to maintain an optimal serum calcifediol concentration (30 ng/mL or
higher) in infants in their first year of life, and that the optimal duration of a supplementation course is not less than 16 weeks.
References:
1. Glants S. Mediko-biologicheskaya statistika. Praktika. 1998, 459.
2. Gromova O. A., Torshin I. Yu., Zakharova I. N., Spirichev V. B., Limanova O. A. [et al.]. O dozirovanii vitamin D u detey I podrostkov. Voprosy sovremennoy pediatrii. 2015;14(1):38–47. doi: 10.15690/vsp.v14i1.1261
3. Gromova O. A., Torshin I. Yu.; pod red. akad. RAN Ye. I. Guseva, prof. I. N. Zakharovoy. Vitamin D – smena paradigm. 2017, 576.
4. Zakharova I. N., Klimov L. Ya., Kuryaninova V. A., Dolbnya S. V., Maykova I. D. [et al.]. Obespechennost vitaminom D detey grudnogo vozrasta. Rossysky vestnik perinatologii i pediatrii. 2016;61(6):68–76. doi: 10.21508/1027-4065-2016-61-6-68-76
5. Zakharova I. N., Klimov L. Ya., Maltsev S. V., Malyavskaya S. I., Gromova O. A. [et al.]. Korrektsiya nedostatochnosti vitamina D u detey rannego vozrasta v Rossyskoy Federatsii (rezultaty issledovaniya RODNIChOK-2). Pediatriya. Prilozheniye k zhurnalu Consilium Medicum. 2017;1:73–81.
6. Zakharova I. N., Yablochkova S. V., Dmitriyeva Yu. A. Izvestnye I neizvestnye effekty vitamina D. Voprosy sovremennoy pediatrii. 2013;12(2):20–26. doi:10.15690/vsp.v12i2.616
7. Zakharova I. N., Klimov L. Ya., Kuryaninova V. A., Gromova O. A., Dolbnya S. V. [et al.] Effektivnost profilaktiki gipovitaminoza D u detey pervogo goda zhizni: rol vskarmlivaniya, vliyaniye dozy I dlitelnosti primeneniya preparatov kholekaltsiferola. Pediatriya. Zhurnal im. G. N. Speranskogo. 2016;95(6):62–69. doi: 10.24110/0031-403X-2016-95-6-62-70
8. Maltsev S. V., Mansurova G. Sh. Metabolizm vitamina D I puti realizatsii ego osnovnykh funktsy. Prakticheskaya meditsina. 2014;9(85):12–18.
9. Natsionalnaya programma «Nedostatochnost vitamin D u detey I podrostkov v Rossyskoy Federatsii: sovremennye podkhody k korrektsii». 2017, 50.
10. Rudyk A. V. Rol vitamina D v protivoinfektsionnom immunitete. Epidemiologiya i infektsionnye bolezni. Aktualnye voprosy. 2017; 1: 54–57.
11. Ahlawat R., Weinstein T., Pettei M.J. Vitamin D in pediatric gastrointestinal disease. Curr. Opin. Pediatr. 2017;29 (1):122–127. doi: 10.1097/MOP.0000000000000451
12. Alonso A., Rodríguez J., Carvajal I., Prieto M. L., Rodríguez R. M. [et al.] Prophylactic vitamin D in healthy infants: assessing the need. Metabolism. 2011;60(12): 1719–1725. doi: 10.1016/j.metabol.2011.04.011
13. Auter Ph., Gandini S.Vitamin D supplementation and total mortality. Arch. Intern. Med. 2007;167(16):1730–1737. doi: 10.1001/archinte.167.16.1730
14. Munns C. F., Shaw N., Kiely M., Specker B. L., Thacher T. D. [et al.] Global consensus recommendations on prevention and management of nutritional rickets. J. Clin. Endocrinol. Metab. 2016;101(2):394–415. doi: 10.1210/jc.2015-2175
15. Grant W. B. The role of vitamin D supplements in treating health condition and diseases common among those with intellectual and/or developmental disabilities. Standardy Medyczne pediatria. 2015;12(5):775–780.
16. Hanson C., Armas L., Lyden E., Anderson-Berry A. Vitamin D status and associations in newborn formula-fed infants during initial hospitalization. J. Am. Diet Assoc. 2011;111(12):1836–1843. doi: 10.1016/j.jada.2011.09.010
17. Holick M. F. Vitamin D status: measurement, interpretation, and clinical application. Ann. Epidemiol. 2009;19(2):73–78. doi:10.1016/j.annepidem.2007.12.001
18. Holick M. F., Binkley N. C., Bischoff-Ferrari H. A., Gordon C. M., Hanley D. A. [et al.].Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 2011;96:1911–1930. doi: 10.1210/jc.2011-0385
19. Holick M. F. Vitamin D deficiency. N. Engl. J. Med. 2007;357:266–281. doi:10.1056/NEJMra070553
20. Klimov L. Ya., Kuryaninova V. A., Zakharova I. N., Dolbnya S. V., Kasyanova A. N.[et al.] Influence of duration of cholecalciferol products administration on the efficacy of hypovitaminosis D prevention in children during the first year of life. Eur. J. Pediatrics. 2016;175(5):343.
21. Kumar J., Muntner P., Kaskel F. J., Hailpern S. M. MLM Prevalence and associations of 25-hydroxyvitamind D deficiency in US children: NHANES 2001–2004. Pediatrics. 2009;124:362–370. doi: 10.1542/peds.2009-0051
22. Pludowski P., Holick F., Grant W. B., Konstantynowicz J., Mascarenhas M. R.[et al.].Vitamin D supplementation guidelines. J. Steroid Biochem. Mol. Biol. 2017; 12: pii: S0960-0760(17)30031-6. doi: 10.1016/j.jsbmb. 2017.01.021
23. Streym S., Højskov C. S., Møller U. K., Heickendorff L., Vestergaard P. [et al.] Vitamin D content in human breast milk: a 9-mo follow-up study. Am. J. Clin. Nutr. 2016;103(1):107–114. doi: 10.3945/ajcn.115.115105
24. Wall C. R., Stewart A. W., Camargo C. A., Scragg R., Mitchell E. A. [et al.] Vitamin D activity of breast milk in women randomly assigned to vitamin D3 supplementation during pregnancy. Am. J. Clin. Nutr. 2016;103(2):382–388. doi: 10.3945/ajcn.115.114603
Keywords: cholecalciferol, vitamin D insufficiency, infants, first year of life, prevention, duration of supplementation, feeding