Medical news
of the North Caucasus
Scientific journal
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Series ПИ #ФС 77-26521.
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ISSN 2073-8137

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Peculiarities of IL-29 production in patients with chronic virus hepatitis C

Natalya Geyvandova; Andrey Lipov; Sofia Rogova;

107 patients with chronic viral hepatitis C (CVHC) were examined. The polymorphism of the IL-28B gene rs12979860 and the content of IL-28B in the blood have been studied. With CVHC more often than in a healthy population, there is the genotype T/T IL-28B and, more rarely, the C/C genotype. The low blood level of IL-29 in CVHC was associated with the genotype T/T IL-28B. Decreased production of IL-29 may be one of the factors contributing to the chronization of HCV infection.


1. Dolganiuc A., Kodys K., Marshall C., Saha B., Zhang S., Bala S. PLoS ONE. 2012;7(10):e44915. doi: 10.1371/journal.pone.0044915
2. Ge D., Fellay J., Thompson A. J., Simon J. S. Nature. 2009;461(7262):399-401.
3. Grebely J., Petoumenos K., Hellard M., Matthews G. Hepatology. 2010;52(4):1216-1224.
4. Langhans B., Kupfer B, Braunschweiger I., Arndt S., Schulte W., Nischalke H. D., Nattermann J., Oldenburg J., Sauerbruch T., Spengler U. J. Hepatol. 2011;54(5):859-865. doi: 10.1016/j.jhep.2010.08.020
5. Pagliaccetti N. E., Robek M. D. Viruses. 2010;2:1589-1602. doi: 10.3390/v2081589

Keywords: chronic viral hepatitis C, interferons, interleukins, prognosis

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy