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[Internal diseases]
Anna Bykova; Irina Kozlova;
The clinical and morphological features of the colon, concentration of cytokines large intestine mucosa and intestinal microbiota in patients with chronic pancreatitis were studied. The objects were 113 patients with chronic pancreatitis. The frequency of intestinal dysfunction, endoscopic and morphological changes in the colon mucosa and concentration of interleukin-2, interleukin-6 and interleukin-8 in the colon biopsy specimens were analysed. Chronic pancreatitis was associated with the functional and structural changes of the colon. The content of pro-inflammatory cytokines in the colon mucosa was increased.
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Keywords: chronic pancreatitis, colon mucosa, biopsy, pro-inflammatory cytokines, colon microbiome