Medical news
of the North Caucasus
Scientific journal
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Series ПИ #ФС 77-26521.
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ISSN 2073-8137

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Histochemical study of plastic function of odontoblasts under the influence of parotine in animal experiments

[Experimental medicine]
Sergey Sirak; Evgeny Shchetinin; Tatyana Kobylkina; Marina Vafiadi; Natalia Bykova;

The article considers the issues of assessing the impact of parotine on the contents of nucleic acids and functional groups of proteins in odontoblasts of the pulp of the lower incisors of sheep. The experiment studied histochemical ultrastructure of the crown and root pulp of 96 permanent lower incisors of 12 yearling sheep, which have teeth with fully formed roots at this age, belonging to the milk dentition. It is established that parotine in a dose of 2 mg/kg causes an increase in the concentration of functional groups of proteins and nucleic acids in odontoblasts, but at a higher dose (10 mg/kg) their content is reduced. The results of the study complement the existing ideas about the pathophysiological mechanisms of stimulation of the reparative function of the tooth pulp and accelerate dentinogenesis under the influence of small doses of parotine.


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Keywords: pulp, odontoblast, parotine, nucleic acids

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy