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https://doi.org/10.14300/mnnc.2017.12013

Growth factors in tussues of ovarian cancer at various stages

[Oncology]
Oleg Kit; Elena Frantsiyants; Tatyana Moiseenko; Ekaterina Verenikina; Natalia Cheryarina; Larisa Kozlova; Yulia Pogorelova;

Levels of endothelial growth factor VEGF-A and its receptor sVEGF-R1, epidermal growth factor EGF and its receptor sEGF-R and tumor necrosis factor TNF-α were studied in tissue samples obtained from 76 patients with epithelial ovarian cancer (serous cystadenocarcinoma) and 47 patients with benign ovarian tumors (cystadenoma). 20 ovarian tissue samples obtained during the surgery for hysteromyoma were used as conditionally intact tissue. Development of epithelial ovarian cancer was revealed to be accompanied by a progressive activation of angiogenic activity in tumor tissue due to the increased expression of the free forms of growth factors: first VEGF and then EGF, and maintained by the increased TNF-α level. The results obtained for the contralateral ovaries are of special interest, as they allow lifting the veil on pathogenesis of ovarian malignant transformation.

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Keywords: ovarian cancer, growth factors, contralateral ovary, VEGF-А, sVEGF-R1, EGF, sEGF-R, TNF-α