of the North Caucasus
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Features of microvascular reactivity in patients with bronchial asthma combined with arterial hypertension and ischemic heart disease
[Original research] [Internal diseases]
Aziza Akhmineeva; Olga Polunina; Irina Sevostyanova; Lyudmila Voronina;
The aim was to study the characteristics of microvascular reactivity on ionophoresis of endothelium-dependent vasodilator in patients with bronchial asthma (BA) comorbid to arterial hypertension (AH) and ischemic heart disease (IHD). We examined 35 patients with BA, 35 patients with AH, 35 patients with IHD, 40 patients with a combination of
BA+AH and 40 patients with a combination of BA+IHD. Based on laser Doppler flowmetry, in each case, a conclusion was made on the type of response of the microvascular endothelium. It was revealed that the hyporeactive-decremental type of response predominates in the IHD group (57 %), whereas the patients with AD are characterized by normal
(69 %) or elevated (31 %) sensitivity of the microvascular receptors. In patients with comorbid pathology the incidence of endothelial hyperreactivity was increased: 75 % in patients with BA+AG and 55 % in patients with AD+IHD. Thus, in all groups of patients a decrease in the duration of vasodilation (decremental types) was observed, indicating the
development of endothelial dysfunction.
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Keywords: types of response of the microvascular endothelium, endothelial dysfunction, bronchial asthma, arterial hypertension, ischemic heart disease
Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy