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Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
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The influence of premedication containing mexidol on cortisol level and number of β-adrenergic receptors in the postoperative period

[Abstracts]
Vladimir Baturin; Vasiliy Fisher; Sergey Sergeev; Ivan Yatsuk;

The article presents the data on the influence of Mexidol as part of the standard scheme of sedation by the number of β-adrenergic receptors and the cortisol concentration in the perioperative period. Patients were examined the day before surgery, during surgery, 3 and 5 days after surgery. Cortisol levels after surgery were significantly increased, and on the
third day – significantly decreased compared to baseline. Mexidol prevented the decrease of cortisol level lower than the initial value, and limited the increase of β-adrenergic receptors in the perioperative period as well as. Thus, Mexidol, being the part of the standard scheme of sedation, probably, limits the stress reaction and its damage effects.

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References:
1. Baturin V. A., Fisher V. V., Sergeev S. A., Yatsuk I. V. Saratovskiy nauchno-meditsinskiy zhurnal. – Saratov Journal of Medical Scientific Research. 2014;10(1):167- 170.
2. Baturin V. A., Fisher V. V., Sergeev S. A., Yacuk I. V. Meditsinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2015;10(1):99-100.
3. Bolshakov A. A., Glagolev N. S., Zaradey I. I. Gerontologiya. – Gerontology. 2014;2(3):297-304.
4. Dygalo N. N., Kalinina T. S., Nosova A. V. Rossijskij Fiziologicheskij zhurnal im. I.M. Sechenova. – Russian Journal of Physiology (formerly I. M. Sechenov Physiological Journal). 1998;84(10):1115-1120.
5. Kehlet H. Br. J. Anaesth. 1989;63:189-195.

Keywords: surgery stress, Mexidol, β-adrenergic receptors, cortisol


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