Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137

Site search

Correspondence address
310 Mira Street, Stavropol, Russia, 355017

+7 8652 352524; +7 8652 353229.

+7 8652 352524.


The influence of premedication containing mexidol on cortisol level and number of β-adrenergic receptors in the postoperative period

Vladimir Baturin; Vasiliy Fisher; Sergey Sergeev; Ivan Yatsuk;

The article presents the data on the influence of Mexidol as part of the standard scheme of sedation by the number of β-adrenergic receptors and the cortisol concentration in the perioperative period. Patients were examined the day before surgery, during surgery, 3 and 5 days after surgery. Cortisol levels after surgery were significantly increased, and on the
third day – significantly decreased compared to baseline. Mexidol prevented the decrease of cortisol level lower than the initial value, and limited the increase of β-adrenergic receptors in the perioperative period as well as. Thus, Mexidol, being the part of the standard scheme of sedation, probably, limits the stress reaction and its damage effects.


1. Baturin V. A., Fisher V. V., Sergeev S. A., Yatsuk I. V. Saratovskiy nauchno-meditsinskiy zhurnal. – Saratov Journal of Medical Scientific Research. 2014;10(1):167- 170.
2. Baturin V. A., Fisher V. V., Sergeev S. A., Yacuk I. V. Meditsinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2015;10(1):99-100.
3. Bolshakov A. A., Glagolev N. S., Zaradey I. I. Gerontologiya. – Gerontology. 2014;2(3):297-304.
4. Dygalo N. N., Kalinina T. S., Nosova A. V. Rossijskij Fiziologicheskij zhurnal im. I.M. Sechenova. – Russian Journal of Physiology (formerly I. M. Sechenov Physiological Journal). 1998;84(10):1115-1120.
5. Kehlet H. Br. J. Anaesth. 1989;63:189-195.

Keywords: surgery stress, Mexidol, β-adrenergic receptors, cortisol

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy