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The article presents the data on the influence of Mexidol as part of the standard scheme of sedation by the number of β-adrenergic receptors and the cortisol concentration in the perioperative period. Patients were examined the day before surgery, during surgery, 3 and 5 days after surgery. Cortisol levels after surgery were significantly increased, and on the
third day – significantly decreased compared to baseline. Mexidol prevented the decrease of cortisol level lower than the initial value, and limited the increase of β-adrenergic receptors in the perioperative period as well as. Thus, Mexidol, being the part of the standard scheme of sedation, probably, limits the stress reaction and its damage effects.
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Keywords: surgery stress, Mexidol, β-adrenergic receptors, cortisol