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of the North Caucasus
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Series ПИ #ФС 77-26521.
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ISSN 2073-8137

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Is there a relationship between insulin resistance, erectile dysfunction and the level of serum total testosterone in men with type 2 diabetes mellitus

Irina Khripun; Igor Belousov; Sergey Vorobyev; Valentina Puzyreva; Yanina Allakhverdieva; Halid Ibishov; Michail Kogan;

The aim of the study was to evaluate the influence of serum total testosterone (T) on the insulin resistance (IR) and erectile dysfunction in men with type 2 diabetes mellitus (T2DM). Objects were 131 male aged 40-65 years with T2DM. Symptoms of erectile dysfunction and androgen deficiency were assessed by IIEF-5 and AMS questionnaires, IR – by HOMA index. Patients were divided into four groups depending on the level of total T. Weight, body mass index and waist circumference were significantly increased in patients with a decreased level of T. The severity of IR negatively correlated with the T levels. Severity of the symptoms of androgen deficiency and erectile dysfunction increases with the decrease in T levels accompanied by worsening of IR in men with T2DM. Supported by Russian Science Foundation, grant № 14-25-00052


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Keywords: testosterone, diabetes mellitus, insulin resistance, erectile

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy