Medical news
of the North Caucasus
Scientific journal
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Series ПИ #ФС 77-26521.
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ISSN 2073-8137

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Markers of endothelial dysfunction in men with type 2 diabetes and their clinical significance

Irina Khripun; Elizaveta Dzantieva; Sergey Vorobyev; Zalina Gusova; Maksim Morgunov; Igor Belousov; Michail Kogan;

We examined 115 men (mean age 54,2±6,2 ys) with type 2 diabetes. The endothelial dysfunction was assessed using biochemical markers (VCAM-1, Р-selectin and Е-selectin) and doppler ultrasound of the brachial artery. To evaluate the severity of symptoms of diabetes mellitus was used the DSC questionnaire. The study revealed a close relationship between VCAM-1 level and biochemical parameters of lipid metabolism. The level of P-selectin was more influenced on the neurological symptoms of diabetes, as well as parameters of endothelium dependent vasodilatation of blood vessels. E-selectin was correlated with the severity of the diabetic symptoms.


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Keywords: endothelial dysfunction, type 2 diabetes mellitus, endothelium dependent v asodilation

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy