Medical news
of the North Caucasus
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Series ПИ #ФС 77-26521.
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ISSN 2073-8137

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Levels of endothelin -1 in the serum of patients with essential hyper tension according to gender and age

Hanicha Ibragimova; Suleyman Mammaev; Zemfira Abusueva;

The results of studies of serum endothelin-1 in patients with arterial hypertension according to gender and age. A significant increase in the endothelin-1 levels in patients with arterial hypertension in serum compared with healthy people. The highest concentration of endothelin-1 levels was found in patients with arterial hypertension in postmenopausal women group. In addition, significant correlation was found between serum levels of endothelin-1, both on the average daily value of systolic blood pressure, and the average value of pulse pressure in a group of women in menopause. Our results suggest that endothelin is one of the most powerful vasoconstrictor factors that contribute the development of hypertension in menopausal women.


1. Belenkov Yu. N., Fomin I. V., Baldin Y. V., Polyakov D. S., Mareev V. Y., Ageev F. T. Problemy zhenskogo zdorovya. –
Women’s Health Problems. 2011;6(4):5-11.
2. Podzolkov V. I., Bragina A. E., Rodionova J. N., Panferova E. K. Consilium Medicum. 2009;11(5):49-54.
3. Shalnova S. A., Balanova Y. A., Konstantinov V. V. Rossysky kardiologichesky zhurnal. – Russian Cardiology Journal. 2006;4:45-50.
4. Bakker E. N., Buus C. L., Vanbavel E., Mulvany M. J. J. Vasc. Res. 2004;41:174-182.

Keywords: arterial hypertension, gender differences, endothelial dysfunction

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy