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The results of studies of serum endothelin-1 in patients with arterial hypertension according to gender and age. A significant increase in the endothelin-1 levels in patients with arterial hypertension in serum compared with healthy people. The highest concentration of endothelin-1 levels was found in patients with arterial hypertension in postmenopausal women group. In addition, significant correlation was found between serum levels of endothelin-1, both on the average daily value of systolic blood pressure, and the average value of pulse pressure in a group of women in menopause. Our results suggest that endothelin is one of the most powerful vasoconstrictor factors that contribute the development of hypertension in menopausal women.
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Keywords: arterial hypertension, gender differences, endothelial dysfunction