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ISSN 2073-8137

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Dynamic of morphological changes in border zone during myocardial infarction organization

Yulia Korneva; Alexander Dorosevich;

Myocardial fragments from the necrotic zone and peri-infarction zone (PZ) were taken from 105 patients, who died during different periods of acute and recurrent myocardial infarction (MI). Cellular populations were counted in 10 fields of view, apoptosis of cardiomyocytes was measured by semiquantative method using CPP-32; capillary bed area (CBA) was measured using CD34 monoclonal antibodies in the computer program «Videotest 4.0. Morphology». Statistical analysis revealed a difference in changing of the studied parameters in the organization of acute and recurrent MI. Major quantitative changes are associated with lymphocytes, neutrophil granulocytes and fibroblasts. Earlier and marked increase was noted in the number of lymphocytes and fibroblasts in the PZ in the organization of recurrent infarction; CBA increase in PZ in response to ischemic injury with subsequent earlier reduction is also characteristic of recurrent infarction. Apoptosis of cardiomyocytes in the PZ increases significantly every time when the necrosis zone occurs, further aggravated in the process of maturation of granulation tissue, and thereby contributing to the expansion of the damaged area.


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Keywords: myocardial infarction, postinfarction remodeling, apoptosis, peri-infarction zone, microcirculation

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy