logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 865 2352511, +7 865 2353229.

E-mail
medvestnik@stgmu.ru

Serum levels of some mediators of bone tissue metabolism in women with rheumatoid arthritis

[Internal diseases]
Vijaya Sarithala; Pavel Koroy; Alexandr Yagoda;

Serum levels of osteocalcin and parathormone were studied in 74 women with rheumatoid arthritis in interrelation with various variants of the disease. Disorders of bone tissue metabolism in the form of decreased levels of osteocalcin, interfaced to activity and functional class were observed in rheumatoid arthritis. Concentration of osteocalcin in blood less than lower normal range was present in 23 % of patients. Indicators of parathormone above the upper normal range were revealed in 12.2 % of cases. Low levels of osteocalcin in rheumatoid arthritis testify to insufficient intensifying of bone formation process in reply to activation of bone resorption. It dictates the necessity of estimation of biochemical markers of bone metabolism for prevention of osteoporosis development.

Download

References:
1. Antonova S. M., Bugrova O. V., Aleksandrova I. A., Ovchinnikova N. A. Nauchno-praktich. revmatol. – Scientific and practical rheumatology. 2010;4:48-53.
2. Balabanova R. М. Sovremen. revmatol. – Modern rheumatology. 2012;3:66-68.
3. Kasumova К. А., Satibaldiev А. М., Smirnov А. V. Nauchno- praktich. revmatol. – Scientific and practical rheumatology. 2004;1:60-63.
4. Raskina Т. А. Kompleksnaya otsenka metabolizma kostnoy tkani u bolnykh revmatoidnym artritom. Kemerovo. 2002; 40 р.
5. Raskina Т. А., Letaeva М. V. Sovremen. revmatol. – Modern rheumatology. 2013;4:18-22.
6. Totrov I. N. Mekhanizmy razvitiya osteoporoza u bolnykh revmatoidnym artritom. Yaroslavl. 2006; 38.
7. Trusov V. V., Bagenov A. N., Filimonov M. A. Problemi expertizi v medicine. – Examining problem in medicine. 2005;5(3):49-51.
8. Aschenberg S., Finzel S., Schmidt S., Kraus S., Engelke K., Englbrecht M., Rech J., Schett G. Arthritis Res. Ther. 2013;15:R62.
9. Batmaz İ., Çakirca G., Sariyildiz M. A., Dilek B., Mete N., Hamidi C., Bozkurt M., Yildiz M., Polat C., Çevik R. Acta. Medica. Mediterranea. 2014;30:397-401.
10. Bellana M., Pirisi M., Sainaghi P. P. Rev. Bras. Reumatol. 2015;55(3):256-263.
11. Ding J., Ghali O., Lencel P., Broux O., Chauveau C., Devedjian J. C., Hardouin P., Magne D. Life Sci. 2009;84:499-504.
12. Gheita T., Fawzy S., Rizk A., Hussein H. The Egyptian Rheumatologist. 2011;33:155-162.
13. Guler-Yuksel M., Bijsterbosch J., Goekoop-Ruiter man Y. P. M., de Vries-Bouwstra J. K., Hulsmans H. M., de Beus W. M., Han K. H., Breedveld F. C., Dijkmans B. A., Allaart C. F., Lems W. F. Ann. Rheum. Dis. 2008;67(6):823-828.
14. Guler-Yuksel M., Allaart C. F., Goekoop-Ruiterman Y. P., de Vries-Bouwstra J. K., van Groenendael J. H., Mallée C., de Bois M. H., Breedveld F. C., Dijkmans B. A., Lems W. F. Ann. Rheum. Dis. 2009;68(3):330-336.
15. Haugeberg G., Green M. J., Quinn M. A., Marzo-Ortega H., Proudman S., Karim Z., Wakefield R. J., Conaghan P. G., Stewart S., Emery P. Ann. Rheum. Dis. 2006;65(6):736-740.
16. Karmakar S., Kay J., Gravallese E. M. Rheum. Dis. Clin. North. Am. 2010;36(2):385-404.
17. Kaur K., Hardy R., Ahasan M. M., Eijken M., van Leeuwen J. P., Filer A., Thomas A. M., Raza K., Buckley C. D., Stewart P. M., Rabbitt E. H., Hewison M., Cooper M. S. Ann. Rheum. Dis. 2010;69(6):1185-1190.
18. Moghimi J., Sadeghi A., Malek M., Ghorbani R. Endocr. Regul. 2012;46(2):61-66.
19. Rossini M., Viapiana O., Adami S., Fracassi E., Idolazzi L., Dartizio C., Povino M., Orsolini G., Gatti D. Clin. Exp. Rheumatol. 2015;33(1):77-83.
20. Seriolo B., Ferretti V., Sulli A. O., Caratto E., Fasciolo D., Cutolo M. Ann. N.Y. Acad. Sci. 2002;966:502-507.
21. Shankar S., Handa R. US Musculoskeletal Review. 2010;5:33-35.
22. Tanabe N., Ito-Kato E., Suzuki N., Nakayama A., Ogiso B., Maeno M., Ito K. Life Sci. 2004;75(19):2317-2327.
23. Vinod A. N., Nalini G., Amarabalan R., Rajasekhar G. Int. J. Cur. Biomed. Phar. Res. 2011;1(3):124-126.
24. Wei S., Kitaura H., Zhou P., Ross F. P., Teitelbaum S. L. J. Clin. Invest. 2005;115 (2):282-290.
25. Yao Z., Li P., Zhang Q., Schwarz E. M., Keng P., Arbini A., Boyce B. F., Xing L. J. Biol. Chem. 2006;281(17):11846- 11855.

Keywords: rheumatoid arthritis, osteocalcin, parathormone


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy