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of the North Caucasus
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ISSN 2073-8137

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Histochemical characteristics of reparative dentinogenesis of the tooth pulp when using tissue -engineered structures

[Original research] [Experimental medicine]
Sergey Sirak; Evgeny Shchetinin; Tatyana Kobylkina; Olga Dilekova; Alla Sirak; Liana Parazyan; Marina Vafiadi;

The role of C-kit-positive cells of the tooth pulp in optimization of reparative dentinogenesis in biological methods of treatment of pulpitis in exremental animals was studied. A model of acute pulpitis with subsequent amputation of the vital pulp was received in vivo on 80 incisors of the lower jaw of he-sheep. The use of tissue-engineered construction composed of collagen sponge, hydrogel PuraMatrix/3DM and ectomesenchymal cells as a biological methods of treatment has allowed to protect better the pulp against infection, to optimize the inflammatory process with the activation of proliferation and acceleration of formation of dentinal bridge.


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Keywords: pulpitis, tissue-engineered construction, ectomesenchymal cells

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy