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ISSN 2073-8137

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The influence of experimental hypo- and hypercalcemia on calcium, lead and zinc content in the femur of rats with short-term lead and zinc intoxication

[Original research] [Experimental medicine]
Varvara Ahpolova; Vadim Brin; Regina Tsallaeva;

The concentrations of calcium, lead and zinc in bone tissue of rats with short-term lead and zinc intoxication, both isolated and in conditions of hypo-and hypercalcaemia were studied. It is shown that experimental hypoparathyroidism slightly mitigates the effect of lead acetate intragastric administration on the bone tissue, but doesn’t change significantly the manifestations of short-term zinc intoxication. Calcitonin hypocalcaemia, experimental hypervitaminosis D increase the accumulation of lead and zinc in the bone matrix in their intragastral admission. In parathyroidectomized rats with subcutaneous injections of metals the largest shifts in the mineral composition of the bone tissue are observed – marked calcification of the bones with parallel accumulation of lead and zinc takes place. Experimental hypercalcaemia, created by both ways, on the contrary, is characterized by the higher concentrations of calcium and low rates of lead and zinc accumulation in femur in their parenteral intake.


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Keywords: hypocalcaemia, hypercalcaemia, intoxication, lead, zinc, calcium, bone tissue

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy