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https://doi.org/10.14300/mnnc.2016.11065

Relationship of plasma levels of adhesion molecules and geometrical models of left ventricle in patients with mitral valve prolapse

[CTD in adults]
Alexandr Yagoda; Natalia Gladkikh;

To determine the relation of plasma E-, L-, P-selectines, type 1intercellular adhesion molecule (ICAM-1), type 1 platelet-endothelial cell adhesion molecule (PECAM-1) and type 1vascular cell adhesion molecule (VCAM-1) with different types of the left ventricular geometry in patients with mitral valve prolapse (MVP). 89 patients (68 male and 21 women, aged 22.1±4.4 years) with MVP were examined. The control group consisted of 10 age- and sex-matched healthy subjects. The normal geometry of the left ventricle was found in 79.8 % of patients with MVP, eccentric and concentric hypertrophy were found in 19.1 % and 1.1 % of cases, respectively. The maximum level of ICAM-1 was observed in patients with MVP and eccentric hypertrophy of the left ventricle. The concentrations of E selectin and VCAM-1 were characterized by high levels regardless of the type of a geometrical model of the left ventricle. The levels of L-, P-selectines and PECAM 1 had no significant differences compared with the control. Thus, the eccentric hypertrophy of left ventricular myocardium in patients with MVP is associated with hyperproduction of ICAM-1.

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Keywords: mitral valve prolapse, adhesion molecules, myocardial remodeling