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of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
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Correlation between fibrinogen beta-chain gene polymorphism, plasma fibrinogen and thromboembolic complications in patients with atrial fibrillation

[Abstracts]
Natalya Bulgakova; Madina Baikulova; Elena Scheglova; Vladimir Kolesnikov; Alexandr Yagoda; Olga Boeva;

In a prospective cohort study the effect of the fibrinogen β-chain gene polymorphism -455G-A and fibrinogen plasma levels on the risk of stroke and systemic thromboembolism in 102 patients (83.3 % men, mean age 52.9±8.4 yrs) with non-valvular atrial fibrillation. Identification of fibrinogen B gene 455G-A polymorphism can be useful to customize the anticoagulation strategy in patients with atrial fibrillation.

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References:
1. Aksyutina N. V., Nikulina S. Yu., Shulman V. A., Maksimov V. N., Nazarov B. V. et al. Vzaimosvyaz polimorfizma gena beta-tsepi fibrinogena s razvitiyem ostrogo narusheniya mozgovogo krovoobrashcheniya v semyakh bolnykh s fibrillyatsiyey predserdy. Vestnik aritmologii 2013;71:26-29.
2. Lip G. Y. H., Nieuwlaat R., Pisters R., Lane D. A., Crijns H. J. G. M. Refining Clinical Risk Stratification For Predicting Stroke And Thromboembolism In Atrial Fibrillation Using A Novel Risk Factor-Based Approach: The Euro Heart Survey On Atrial Fibrillation. Chest 2010;137(2):263-272. doi:10.1378/chest.09-1584
3. Shulman V. A., Aksyutina N. V., Nikulina S. Yu., Nazarov B. V., Dudkina K. V. et al. Geneticheskiye prediktory kardioembolicheskogo insulta u bolnykh s fibrillyatsiyey predserdy. Rossysky kardiologichesky zhurnal. 2014;10(114):29-33.
4. Springer T. A., Zhu J., Xiao T. Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin αIIbβ3. The Journal of Cell Biology 2008;182(4):791-800. doi: 10.1083/jcb.200801146
5. Sulimov V. A., Golitsyn S. P., Panchenko Ye. P., Popov S. V., Revishvili A. Sh. et al. Diagnostika i lecheniye fibrillyatsii predserdy. Rekomendatsii RKO, VNOA i ASSKh. Rossysky kardiologichesky zhurnal. 2013;4s3(102):1-100

Keywords: atrial fibrillation, fibrinogen, thromboembolic complications, genetic polymorphism, fibrinogen β-chain gene


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy