• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2016.11040

Role of gelatinase B and intraerythrocytic magnesium in formation of the chronic endometrium inflammation in rats

[Experimental medicine]
Lyudmila Rogova; Ksenya Tikhaeva; Lyudmila Tkachenko;

In the study was evaluated the role of intraerythrocytic magnesium, the specific number and intensity of expression of gelatinase B positive cells on the mechanisms of chronic experimental inflammation of the endometrium in rats. Experiment was performed on 40 adult female white Wistar rats, which were divided into 3 groups. The first group (n=10) – initial state, the second group (n=10) – control series, the third group (n=10) – simulation of endometritis. On the 51st day after modeling chronic inflammation of the endometrium of the rats were receiving the blood from the inferior Vena cava and subclavian veins, the tissue of the uterine wall. Our study showed a reduction in the specific number of gelatinase В positive cells in the stroma (cellular component), the intensity of expression decreased of gelatinase-B in both the stroma and glandular epithelium. The decrease in intraerythrocytic levels of magnesium in the blood from different regions is a strong direct correlation with the number and intensity of expression gelatinase B. Thus, the decrease of intraerythrocytic magnesium, immunohistochemically activity indicators of gelatinase B on the background of the morphological picture of chronic endometritis, act as important links of the chronic endometrium inflammation.

Download

References:
1. Gromova O. A. Magnesium and pyridoxine: basic knowledge Prototype. 2006. 234 p.
2. Poteryaeva O. N., Antonov A. R., Kim N. A., Nekrasova M. F. Fundamental and applied problems of medicine and biologii. 2006. 40 p.
3. Rogova L. N. Matrix metalloproteinases, and their role in physiological and pathological processes (review). Vestn. new medic. technologies. 2011;8(2):86-89.
4. Rogova L. N., Shesternina N. V., Starovoytov V. A. Effect of magnesium composition on magnesium balance, intensity of peroxidation and activity of antioxidant enzymes in rats with gastric ulcer acetate. Vestn. New medic. technologies. 2011;8(2):89-91.
5. Solovyova N. I. Bioorganic Chemistry. 1998;24(4):245-255.
6. Sukhih G. T., Shurshalina A. V. Chronic endometritis: manual. M: «GEOTAR Media»; 2010. 64 p.
7. Tikhaeva K. L., Tkachenko L. V., Rogova L. N., Kurkin D. V. The modeling method of chronic endometrium inflammation and its pathogenetic substantiation Volgograd. Journal of Medical Science. 2015;45(1):31-34.
8. Egeblad M., Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer. 2002;2(3):161-174.
9. Rubin H. The logic of Membrane, Magnesium, Mitosis (MMM) model for the regulation of animal cell proliferation. Science. 2003;261:1280-1281.
10. Baker A. B. Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J. Cell. Science. 2002;115:3719-3727.
11. Inagaki N. Analysis of intrauterine cytokine concentration and matrix-metalloproteinase activity in women with recurrent failed embryo transfer. Human Reproduction. 2003;18(3):608-615.

Keywords: сhronic endometritis, gelatinase, magnesium