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EBSCO

https://doi.org/10.14300/mnnc.2016.11035

Properties of developed niosomal forms of anti-cancer substances N-hydroxy-2-(2-(naphthalen-2-yl)-1H-Indol-3-yl)-2-phenylacetamide in treatment of glioblastoma

[Experimental medicine]
Igor Bazikov; Igor Aksenov; Alexander Maltsev; M. Selimov; Alexander Kornienko; N. Aksenov; Inna Aksenova; Filipp Bazikov;

The physical properties of niosome form of anti-cancer substances Ax7 was studied. Samples of substances scanned in atomic forced microscope. Analyzing the results showed the middle size of niosomes with incapsulated antitumor substance is 100 nm. Microviscosity of niosomes is low and elasticity is high, what ensures the passage of drug through the small capillaries and intercellular space. Silicone niosomes easily integrated into the plasma membrane. This improves transport of Ax7 substances into the cell. The results of obtained study of prototype drug physical properties, demonstrated its high ability to transport anticancer agents Ax7 to glioblastoma.

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Keywords: glioblastoma, anti-cancer substances Ax7, niosomes, atomic force microscopy