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ISSN 2073-8137

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Study of the spectrum of dental composites biological activity in model experiments in vitro

Dmitry Domenyuk; Ernessa Vedeshina; Vladimir Zelenskiy; Karen Karakov; Michail Porfiriadis; Igor Bazikov; F. Gilmiyarova;

The nature of the effect of composite dental materials, based on methacrylate and oxirane, on the structural and functional properties of the blood cells of healthy subjects was investigated in model experiments in-vitro. There were revealed the changes of structural and functional characteristics of red blood cells, indicating the membrane damaging effect of the monomer composites. It is shown that incubation of blood with unpolymerized material causes expressed deformation of the membrane, erythrocyte aggregation. Methacrylate based composites have a more pronounced negative potential due to biodegradation that requires strict compliance with the polymerization conditions. Oxirane based materials are bioinert after polymerization, which allows recommending them for wider application. The study substantiated the feasibility of using of the developed experimental model for biological testing of dental filling materials.


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Keywords: monomers, dental composites, biological activity, blood, red blood cells

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy