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ISSN 2073-8137

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Non-invasive monitoring for local immune and antioxidant resistance in patients with ischemic heart disease and type 2 diabetes

[Original research] [Internal diseases]
Natalia Bykova; Alexander Basov; Karina Melkonyan; Elena Alexeenko; Konstantin Popov; Ilya Bykov;

The item offers a view at the changes taking place in the immunologic responsiveness and the indices for the prooxidant–anti-oxidant system in the blood and in the oral liquid in case of T2D and IHD. There has been a significant IgA increase detected in the oral cavity in cases of T2D coming along with IHD (2.1 times), and IgM – at T2D (4 times). An imbalance has been found in the prooxidant–anti-oxidant system, accompanied by an increase in products of oxidative modification of biomolecules and decreased activity of catalase and superoxide dismutase in blood and oral liquid, especially in case of T2D comorbid with IHD. There has been significant correlation links established between the indices of immunologic responsiveness and the enzymes of anti-radical protection in blood and in oral liquid, as well as direct reliable correlation links between clinical indices for periodontal status and the indicators of non-specific protection in the oral cavity (r=±0,76–0,99).


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Keywords: oral liquid, diabetes mellitus, ischemic heart disease, immunoglobulin, superoxide dismutase

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy