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Association of insulin resistance and obesity with impaired immune response to нepatitis B vaccination in health care workers

[Original research] [Internal diseases]
Larisa Tkachenko; Viktor Maleyev; Ludmila Rtishcheva;

At the study was to evaluate immune response to HBV vaccine in Health care workers (HCWs) and detect risk factors of non-responsible persons. Descriptive retrospective analyses of antibodies’ titer dynamics in 98 HBV vaccinated HCWs conducted from 1998 to 2011 years annually were evaluated by measuring serum HBsAb levels, by objective state and on the main laboratory results taken in medical documents. After vaccination negative response (аHBs<10 mIU/ml) was in 20.4 %, poor immune response (аHBs>10 mIU/ml<100 mIU/ml) – in 34.7 % and high immune response (аHBs>100 mIU/ml) – in 44.9 % HCWs. Оbesity, insulin resistance, аge over 40 years, male gender and low level of 25(OH)D were associated with negative response to vaccination. In titer аHBs<100 mIU/ml, patients became seronegative in three years after vaccination. In high immune response, patients stay seropositive during 10 years. The introduction of a booster dose of the vaccine and activating cellular immunity, can improve the immunogenicity of the vaccine. Thus оbesity insulin resistance, inadequate supply of 25 (OH)D, аge over 40 years and male gender were associated with non response to vaccination. It’s necessary to follow-up of the primary immune response in HCWs in order to specify the additional doses of the vaccine in seronegative patients.


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Keywords: вакцинация, иммунный ответ, вирусный гепатит В, инсулинорезистентность, ожирение, работники здравоохранения

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy