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of the North Caucasus
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ISSN 2073-8137

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The frequency and type of echocardiographic changes in children with connective tissue dysplasia syndrome

Natalia Fedko; Angelina Kalmykova; Valentina Muravyeva; Elina Zurnacheva; Vera Shaytanova; E. Ivanitskaya; Asiyat Dzhanibekova; R. Stupin;

The echocardiographic parameters in 500 children aged 7–16 years with the dysplasia syndrome of the heart connective tissue (DSHCT) were investigated.

The study demonstrated that mitral valve prolapse of 1st or 2nd degree combined with dysfunction of the tricuspid valve and pulmonary valve simultaneously in 2/3 of subjects, while isolated abnormal chord of the left ventricular met almost every second patient. In the cases of mitral valve prolapse of the 1st degree and/or abnormal left ventricular chord the 1st degree of mitral regurgitation prevailed. Mitral valve prolapse of the 2nd degree was accompanied by regurgitation of the 2nd degrees in 81,5 % of cases, and in 23,5 % of puberty girls – be regurgitation of the 3rd degree. Significant echocardiographic changes, such as insufficiency of the mitral and tricuspid valves, atrial septal aneurysm, structural changes of the mitral leaflets, diffuse changes in myocardium were detected more frequently in the cases of mitral valve prolapse of the 2nd degree.


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Keywords: syndrome of connective tissue dysplasia among children, echocardiography

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy