Medical news
of the North Caucasus
Scientific journal
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Series ПИ #ФС 77-26521.
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ISSN 2073-8137

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Stage-by-stage treatment and outcomes of conjugated jaundice in infants

Olesya Pervishko; Victoria Shashel; Valentina Muravyeva;

The aim of the study was to describe stages of treatment of hyperbilirubinemia in infants, including prescription of ursodeoxycholic acid (Ursofalk suspension) according to the scheme: 20–30 mg/kg per day plus the increase of the fluid intake up to 10 ml/kg for premature infant and 20 ml/kg for full-term infant. Detection of possible herpetic infections (CMV, Epstein-Barr virus, HSV type 1 and 2) during followup demand prescription of Interferon alfa-2b in rectal suppository and Genferon Lite 125000 mg according to the scheme. It was found that long-term course of the conjugation jaundice is due to CMV infection in 35 % of cases, due to a combination of CMV and EBV – in 47 % and in 18 % of cases – due to CMV and HSV type 1 and 2. The longest course with signs of cytolysis and hepatomegaly was observed in patients with mixed CMV and EBV infection.


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Keywords: children, hyperbilirubinemia, herpetic infections, outcomes

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy