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ISSN 2073-8137
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Efficiency of peritonitis treatment in experiment depending on the abdominal cavity sanation method

[Surgery]
Igor Suzdaltsev; Valentina Botasheva; Valeria Demyanova; Urii Pykhtin; Sergey Pustii; Alexander Panchenko;

The study of efficiency of different methods of an abdominal cavity sanation was carried out using experimental model (male rats, Wistar, weight 250–300 g) of peritonitis by Blinkov Y. Y. Animals were divided into three groups of 9 rats. Group I – without treatment, group II – sanation by 0,05% water solution of chlorhexidine, group III – sanation by exogenous nitric oxide (time of influence is 0,6 sec. for 1 cm2 of rats peritoneum). It is established that monoxide of nitrogen reduces intensity of hypostasis, vascular disorders, strengthens reparation processes that conducts to subsiding of inflammatory process in an abdominal cavity for 4 days earlier in comparison with application of antiseptics (0,05 % solution of a chlorhexidine), and also reduces a lethality among experimental animals by 2,7 times. It was found that nitric oxide reduces the intensity of edema, vascular damage, enhances the reparative processes, which leads to the reduction of inflammatory process in the abdominal cavity 4 days earlier compared to antiseptic (0,05 % chlorhexidine solution). Nitric oxide 2,7 times reduces mortality in experimental animals.

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Keywords: nitric oxide, experimental peritonitis, sanation of abdominal cavity


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