Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137

Site search

Correspondence address
310 Mira Street, Stavropol, Russia, 355017

+7 865 2352511, +7 865 2353229.


Clinical and biochemical aspects of local therapy for chronic recurrent aphthous stomatitis

Sergey Sirak; Ilya Bykov; Evgeny Shchetinin; Lyudmila Skorikova; Lyutsina Akopova; Alla Sirak; Natalia Bykova; Elena Alexeenko; Feras Mohammed Sami Al Asfari;

The item dwells on issues related to local treatment of the oral mucosa lesions in patients with chronic recurrent aphthous stomatitis. The authors used an adhesive medicine based on a specially engineered formula. The treatment effectiveness was evaluated through the absence of complaints reported by the patients, the rate of aphthae epithelialization, the duration of remission, and some indicators for the oral fluid before and after treatment. The results of the clinical and biochemical studies have shown that the proposed medicine effectively accelerates the disease remission and epithelialization of damaged oral mucosa with the normalization of biochemical and immunological parameters.


1. Akintoye S. O., Greenberg M. S. Recurrent Aphthous Stomatitis. Dental Clinics of North America. 2014;58(2):281-297. doi:10.1016/j.cden.2013.12.002
2. Albrektson M., Hedström L., Bergh H. Recurrent aphthous stomatitis and pain management with low-level laser therapy: A randomized controlled trial. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2014;117(5):590-594. doi:10.1016/j.oooo.2014.01.228
3. Chavan M., Jain H., Diwan N., Khedkar S., Shete A., Durkar S. Recurrent aphthous stomatitis: A review. Journal of Oral Pathology and Medicine. 2012;41(8):577-583. doi:10.1111/j.1600-0714.2012.01134.x
4. Eguia-Del Valle A., Martinez-Conde-Llamosas R., López-Vicente J., Uribarri-Etxebarria A., Aguirre-Urizar J.-M. Salivary levels of Tumour Necrosis Factor-alpha in patients with recurrent aphthous stomatitis. Medicina Oral, Patologia Oral y Cirugia Bucal. 2011;16(1):e33-e36. doi:10.4317/medoral.16.e33
5. Preeti L., Magesh K. T., Rajkumar K., Karthik R. Recurrent aphthous stomatitis. Journal of Oral and Maxillofacial Pathology. 2011;15(3):252-256. doi:10.4103/0973-029X.86669
6. Ruiz Beguerie J., Sabas M. Recurrent aphthous stomatitis. Journal of the Dermatology Nurses’ Association. 2015;7(1):8-12. doi:10.1097/JDN.0000000000000099
7. Sirak S.V., Kopylova I. A., Chebotarev V. V., Al-Asfari F. M.-S. The use of multicomponent adhesive ointment in combination with immunomodulating agent in the treatment of pemphigus. Parodontologiya. 2012;17(2):62-65.
8. Sirak S. V., Shapovalova I. A., Maksimova E. M., Prigodin S. N. Stomatologic desease the children’s population of Stavropol territory before introduction of the program of preventive maintenance. Stomatologiya detskogo vozrasta i prophilaktika. 2009;8(1):64-66.
9. Sirak S. V., Chebotarev V. V., Sirak A. G., Grigorian A. A. The use experience of local wound healing agents in the treatment of pemphigus vulgaris with localization on the oral mucosa and lips. Meditsinskii Vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2013;8(1):59-62.
10. Sirak S. V., Bykov I. М., Sirak A. G., Akopova L. V. Prevention inflammatory periodontal diseases using the elixir of tooth. Kubanskiy nauchniy medicinskiy vestnik. 2013;6:166-169.
11. Williams L. A., Bramwell B. L. Current concepts in the treatment of recurrent aphthous ulcers. International Journal of Pharmaceutical Compounding. 2011;15(1):13-18.

Keywords: stomatitis, mucous membrane, treatment, healing

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy