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ISSN 2073-8137

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Invoked visual potentials in the study of the visual analyzer in patients with diffuse sclerosis

Sergei Karpov; Zaire Padgigova; Aleksey Karpov; Irina Vishlova;

The Purpose of the study was to examine the neurophysiological characteristics of the visual analyzer in patients with multiple sclerosis (MS) to optimize early diagnosis of the disease. The study involved 79 patients (57 women and 22 men), mean age was 34.31±4.7 years with a confirmed diagnosis of multiple sclerosis.

The results of neurophysiological studies have shown that in MS the demyelination processes in the structures of the visual analyzer in a variety of light spectrum not occur equally. The most pronounced significant (p<0.01) deviations in the parameters invoked visual potentials secondary progressive multiple sclerosis on the black and white checkerboard pattern was observed in patients with primary progressive multiple sclerosis and clinical form of the changeover point. The indicator of the latent period of the wave R100 was increased sharply and significantly (p<0.001) differed from the control group. Amplitude analysis made it possible to note a significant decrease in the strength of the response wave N75-N100 black-and-white stimulus in all clinical groups, making up on average of 3,3 mV (control of 8.5 μv). The indicator of the latent period, the red-yellow chess pattern wave R100 was significantly increased and significantly (p<0.001) differed from the control group. Similar changes were observed in green-and-black checkerboard pattern. When examined 25 patients with MS revealed increased levels of IgG antibodies to myelin basic protein.

The changes lead to a sharp decrease in the response of the cortical reaction. The use of color pattern will largely contribute to improving the early diagnosis of multiple sclerosis.


1. Alifirova V. M., Titova M. A. Clinical characteristics of multiple sclerosis in the Tomsk region. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2012;(2):50–51.doi:10.14412/2074-2711-2012-382.
2. Costello F., Coupland S., Hodge W., et al. Quantifying axonal loss after optic neuritis with optical coherence tomography. Ann Neurol. 2006;59(6):963–969. doi:10.1002/ana.20851.
3. Gnezditskii, V. V. Vyzvannye potentsialy mozga v klinicheskoi praktike [The caused potentials of a brain in clinical practice]. Taganrog: TRTU; 1997.
4. Karpov SM, Baturin VA, Tel’bukh VP, et al. Autoantitela to the main protein of a myelin and their role at the demiyeliniziruyushchikh processes. Klinicheskaya nevrologiya. 2013;(3):16–19.
5. Kubarko A. I., Kubarko N. P., Kubarko Ju. A. Light sensitivity of the visual system in patients with demyelinating optic neuropathy in acute retrobulbar neuritis. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2014;114(2–2):40–47.
6. Morquette J. В., Di Polo A. Dendritic and synaptic protection: is it enough to save the retinal ganglion cell body and axon? J. Neuroophthalmol. 2008;28(2):144–154. doi:10.1097/WNO.0b013e318177edf0.
7. Pazhigova Z. B., Karpov S. M., Shevchenko P. P., Burnusus N. I. Prevalence of multiple sclerosis in the world (review). Mezhdunarodnyi zhurnal eksperimental’nogo obrazovaniya. 2014;(1–2):78–82.
8. Rocca M. A., Hickman S. J., Bo L., et al. Imaging the optic nerve in multiple sclerosis. Multiple Scler. 2005;11(5):537–541. doi:10.1191/1352458505ms1213oa.
9. Shmidt T. E., Yakhno N. N. Rasseyannyi skleroz: rukovodstvo dlya vrachei [Multiple sclerosis: the guide for doctors]. 3nd ed. Moscow: MEDpress-inform; 2012. 272 p.
10. Zikhova A. R., Berezgova L. M., Tlapshokova L. B., Boiko A. N. Epidemiological characteristics of multiple sclerosis in the Kabardino-Balkaria Republic. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2013;113(10–2):5–7

Keywords: invoked potentials, visual analyzer, multiple sclerosis

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy