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[Internal diseases]
Bella Shamgunova; Boleslav Levitan; Adelya Sartova;
The study was carried out to examine the association of haplotypes HLA-A-B -DRB1-DQB1 in patients with the pollen allergy of Russian nationality. Patients with pollen allergy (n = 61) were divided into two groups: 1) seasonal allergic rhinitis (n=31); and 2) seasonal allergic asthma (n=30). A total of 61 patients with pollen allergy were analysed for HLA Class II (DRB1, DQB1) by PCR-SSP (Sequence Specific Primers) method. HLA class I genotyping was performed by the lymphocytotoxic reaction. The genetic markers of pollinosis, including seasonal allergic rhinitis and allergic bronchial asthma are established. The HLA-A2-B40-DRB1*15-DQB1*06 haplotype is a risk factor for pollinosis in the inhabitants of the Astrakhan region of Russian nationality. The HLA- А1-В7-DRB1*15-DQB1*06, А2-Вх-DRB1*15-DQB1*06, А2-В7-DRB1*13-DQB1*06, А3-В7-DRB1*15-DQB1*х, А3-В7-DRB1*15-DQB1*06, А19-В7-DRB1*15-DQB1*06, Ах-В7-DRB1*11-DQB1*03 haplotypes showed a negative association with asthma in the patients with seasonal allergic rhinitis.
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Keywords: pollen allergy, allergic rhinitis, allergic asthma, HLA, haplotypes