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Stages of patho- and morphogenesis of chronic hepatopathy at chronic drug intoxication

[Original research] [Morphology]
Olga Ermakova; Irina Kostornaya;

The stages and characteristics of patho- and morphogenesis of chronic hepatopathy at chronic drug intoxication (CDI) have been described in the present paper. Liver tissue sampling of 30 patients of average age 22,7±0,7 years with clinical and laboratory manifestations of CDI were studied. Histological examination of liver biopsy material was performed on paraffin sections stained with hematoxylin and eosin, picrofuxin by Van Gieson and Sudan III. To assess the activity of chronic hepatitis B the index of histological activity (IHA) was determined. The degree of liver fibrosis was evaluated by Sciot and Desmet index. For statistical analysis of the obtained results the software package Statistica 6.0 was used.

Morphological types of chronic hepatopathy were revealed in CDI patients: on the background of fatty hepatosis chronic hepatitis with a low degree of activity develops followed by the formation of monolobular liver cirrhosis with low activity levels. The common morphological form of chronic hepatopathy was a chronic granulomatous hepatitis with low activity. Various morphological forms of chronic hepatopathy in patients with CDI were the stages of its progression that can be considered as morphogenesis of the above hepatopathy resulting in monolobular liver cirrhosis formation.

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Keywords: narcotic, drug addiction, hepatopathy, biopsy