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ISSN 2073-8137
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Results of histological examination of periodontal disease in the application of allogeneic cultured fibroblasts in the experiment

[Original research] [Stomatology]
Igor Bazikov; Valentina Botasheva; Olga Sumkina; Fahriel Muharamov; Nadezhda Penkova; Vera Lukinova; Elena Chekrygina; Dmitry Domenyuk;

Cultured allogeneic fibroblasts were obtained from gingival biopsy that have been used in the treatment of periodontal disease. Histological studies of periodontal lesion were conducted in an experiment. It was revealed that the animals without treatment developed the picture of diffuse purulent periodontitis with severe destructive changes and formation of a deep defect on the 7th day. In the treatment with «Metragil-Denta» focal purulent inflammation developed around the lesion, destructive changes were observed with the formation of a shallow defect. In the treatment with «Regenerin» serous periodontitis developed in the periodontium. The most pronounced reparative processes have been reported with the use of cultured fibroblasts. Histological examination revealed increased fibrillogenesis with the formation of young connective tissue.

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Keywords: fibroblasts, periodontal, histological studies, regeneration


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Pyatigorsk State Research Institute of Balneotherapeutics
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