logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 8652 352524; +7 8652 353229.

Fax
+7 8652 352524.

E-mail
medvestnik@stgmu.ru

Duration of latent period and iron deficiency development in children with celiac disease

[Original research] [Pediatrics]
Leonid Klimov; Victoria Kuryaninova; Marina Stoyan; Dayana Asaturova; Elena Gerasimenko; Madina Daguzhieva;

An analysis of iron deficiency (ID) occurrence was conducted; this involved 126 children with celiac disease depending on the age and the duration of the ailment’s latent period. The general occurrence rate of ID in children with celiac disease was 58.7 %, in those on their first year of life it was diagnosed in 90.0 % of cases, while in preschoolers the rate went down to be on the up again in schoolers (up to 70.0 %). As for the nosological pattern of ID in infants and schoolers, there is prevailing iron deficiency anemia (IDA), while patients aged 1–7 years have latent iron deficiency (LID) prevalent in them. In children with celiac disease the occurrence of IDA in its mild form was 64.9 %, moderate – 32.4 %, severe – 2.7 %.

An increase in the latent period of undiagnosed celiac disease in children and adolescents comes along with progressing depletion in the transport and tissue pool of iron storage, as well as changing quantitative and morphometric features in erythrocytes, which results in a growing occurrence rate of the manifest type of ID – IDA.

Download

References:
1. Belmer S. V., Semenova E. V., Smetanina N. S., Malkoch A. V. Haematologic manifestations of celiac disease. Celiac disease in children. М.: «Publishing House MEDPRACTICA-М»; 2013. P. 261-274.
2. Samsygina G. A., Kazyukova T. V., Levina А. А. Iron deficiency in children and adolescents: causes, diagnostics, treatment, prevention. М.: «Pirogova Russian State Medical University»; 2006. 32 p.
3. Zakharova I. N., Roslavtseva Е. А., Borovik T. E. et al. Clinical variants of celiac disease in Pediatric practice. Issues of Diagnostics in Pediatrics. 2011;3(6):52-58.
4. Parfenov A. I. Celiac disease. Evolution of ideas on prevalence, clinical symptoms, and etiotropic therapy. М.: «Anaharsis»; 2007. 376 p.
5. Sabelnikova E. A., Parfenov A. I., Krums L. M. Celiac disease as a reason behind iron deficiency anemia. Ter. Archives. 2006;2:45-48.
6. Sanakoeva L. P., Diagnostics, treatment, and prevention of iron deficiency anemia in early childhood. Vagner Per-mGMA; 2011. 44 p.
7. Semenova E. V., Belmer S. V., Kazanets E. G. et al. Ane- mia in case of celiac disease in children. Child Hospital. 2012;1:44-49.
8. Stoyan M. V., Kuryaninova V. A., Klimov L. Ya. et al. Occurrence and clinical-anamnestic features in children with iron deficiency through acute stage of celiac disease. Volume of XX Jubilee Congress for Child Gastroenterologists of Russia. М.: «Publishing House MEDPRACTICA-М»; 2013. P. 141-142.
9. Bergamaschi G., Markopoulos K., Albertini R. et al. Anemia of chronic disease and defective erythropoietin production in patients with celiac disease. Haematologica. 2008;93:1785-1791.
10. Carroccio A., Iannitto E., Cavataio F. et al. Sideropenic anemia and celiac disease: one study, two points of view. Dig. Dis. Sci. 1998;43:673-678.
11. de Vizia B., Poggi V., Conenna R., Fiorillo A., Scippa L. Iron absorption and iron deficiency in infants. Pediatr. Gastroenterol. Nutr. 1992;14:21-26.
12. Fisgin T., Yarali N., Duru F. et al. Hematologic manifestation of childhood celiac disease. Acta Haematol. 2004;111:211-214.
13. Halfdanarson T. R., Litzow M. R., Murray J. A. Hematologic manifestations of celiac disease. Blood. 2007;109:412-421.
14. Harper J. W., Holleran S. F., Ramakrishnan R. et al. Anemia in celiac disease is multifactorial in etiology. American Journal of Hematology. 2007;82:996- 1000.
15. Husby S., Koletzko S., Kopronay-Szabo I. R. et al. ESPGHAN guidelines for the diagnosis of coeliac disease. J. Pediatr. Gastroenterol. Nutr. 2012;54(1):136-160.

Keywords: celiac disease, children, anemia, iron deficiency


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy