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https://doi.org/10.14300/mnnc.2014.09037

Complex, three-dimensional reconstruction of critical size defects following delayed implant placement using stem cell-containing subepithelial connective tissue graft and allogenic human bone blocks for horizontal alveolar bone augmentation: a case report as proof of clinical study principles

[Original research] [Surgery]
Wolf-Dieter Grimm; Mathias Plöger; Ingmar Schau; Alexander Vukovic; Evgeny Shchetinin; Albert Akkalaev; Ruzanna Avanesyan; Sergey Sirak;

For three-dimensional reconstruction of defects of the alveolar crest to the conduct of dental implantation today use autogenous blocks grafts from the iliac crest, the pubic symphysis or branches of the lower jaw. The authors evaluate the regeneration potential of the soft tissues of the sky as a new source of stem cells in combination with transplantation of osteoplastic material for building bones and delayed implantation. Developed the method of treatment showed the ability of the bone marrow, stem and progenitor cells for the regeneration of various tissues, including bone.

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References:
1. Matarasso S,, Salvi G.E., Iorio Siciliano V., Cafiero C., Blasi A., Lang N. P. Dimensional ridge alterations following immediate implant placement in molar extraction sites: a sixmonth prospective cohort study with surgical reentry. Clin Oral Implants Res. 2009;20(10):1092- 1098. doi: 10.1111/j.1600-0501.2009.01803.x.
2. Grimm W.-D., Dittmar Th., Varga G., Giesenhagen B. Use of stemcell induced allogenic bonerings for preimplantological vertical augmentations of alveolar bone defects in humans a clinical controlled study. Proceedings, BIT’s 6th Annual World Congress of Regenerative Medicine & Stem Cells-2013, 2013, Dalian, China.
3. Grimm W.-D., Dannan A., Becher S., Gassmann G., Arnold W., Varga G., Dittmar Th. The Ability of Human Periodontium derived Stem Cells to Regenerate Periodontal Tissues-A Preliminary in Vivo Investigation. Int. J . Periodontics Restorative Dent. 2011;31(6):94-101.
4. Plöger, Mathias, Schau I. (ed.). Kieferkammrekonstruktion mit CAD-CAM-gefertigten allogenen Knochenblöcken. Quintessenz Publishing Company 2010.
5. Keeve P. L., Dittmar Th., Gassmann G., Grimm W.-D., Niggemann B., Friedmann A. Characterization and analysis of migration patterns of dentospheres derived from periodontal tissue and the palate Characterization and analysis of migration patterns of dentospheres derived from periodontal tissue and the palate. J. Periodontal. Res. 2013;48(3):276-285. doi: 10.1111/jre.12005.
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7. Sirak S. V., Ibragimov I. M., Kodzokov B. A. The influence of porous titanium for the osteogenic potential of bone marrow cells in vitro. Medical News of North Caucasus. 2012;27(3):22-25.
8. Sirak S. V., Slyotov A. A., Dagueva M. V. The immediate dental implantation in patients with included dentition defects. Medical News of North Caucasus 2011;21(1):51-54.

Keywords: regeneration and transplantation, bone block, jaw