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https://doi.org/10.14300/mnnc.2026.21022

The effect of cholecalciferol supplementation on bone metabolism indicators in children and adolescents with bronchial asthma: results of a prospective study

[Pediatrics]
Svetlana Dolbnya; Viktoriya Romanovna Ponamareva; Anna Aleksandrovna Tolkunova; Leonid Klimov; Natalia Fedko; Natalya Zarytovskaya; Maria Makarova; Аnna Kasyanova;

Patients with bronchial asthma are at risk of bone metabolism disorders regardless of their age. This is due to chronic lung inflammation and the use of standard-of-care medications that can affect bone metabolism. This article presents the results of a study on vitamin D status, parathyroid hormone levels and markers of bone turnover (C-terminal peptides of type I procollagen and osteocalcin) in children and adolescents with asthma receiving cholecalciferol supplementation. The study found a reduction in the proportion of patients with vitamin D deficiency, which was associated with an increase in the level of the bone formation marker (osteocalcin) and a decrease in the bone resorption marker, with no significant change in parathyroid hormone levels. The intensity of baseline therapy had no significant effect on the laboratory parameters studied or on anthropometric parameters; however, those receiving low doses of inhaled steroids demonstrated better vitamin D status. Thus, prophylactic supplementation with cholecalciferol preparations in patients with bronchial asthma leads to an improvement in vitamin D status and has a positive effect on indicators of bone metabolism.

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Keywords: bronchial asthma, bone metabolism, vitamin D, children