• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2025.20084

The potential role of the intestinal microbiota in the pathogenesis and development of bronchial asthma phenotypes in children

[Reviews]
Svetlana Dolbnya; Viktoriya Romanovna Ponamareva; Anna Aleksandrovna Tolkunova; Leonid Klimov; Lyudmila Barycheva; Vera Valentinovna Kuznetsova; Valeria Karenovna Kalaydzhan; Elizaveta Igorevna Monastyrskaya;

Intestinal microbiota plays a central role in regulating both innate and adaptive immune responses. Changes in the composition and function of the intestinal microbiota have been found to be closely associated with fluctuations in immune responses and the development of allergic diseases, including bronchial asthma. Given the clinical heterogeneity of asthma, studying specific microbiomes may prove an important step in comprehending the pathogenetic elements of phenotypes. Modulation of host physiological functions with the microbiota is a promising therapeutic and preventive tool for controlling the burden of atopy.

Download

References:
1. Salameh M., Burney Z., Mhaimeed N., Laswi I., Yousri N. A. [et al.]. The role of gut microbiota in atopic asthma and allergy, implications in the understanding of disease pathogenesis. Scand. J. Immunol. 2020;91(3):e12855. https://doi.org/10.1111/sji.12855
2. Cheng Z. X., Wu Y. X., Jie Z. J., Li X. J., Zhang J. Genetic evidence on the causality between gut microbiota and various asthma phenotypes: a two-sample mendelian randomization study. Front. Cell. Infect. Microbiol. 2024;13:1270067. https://doi.org/10.3389/fcimb.2023.1270067
3. Smulders T., Van Der Schee M. P., Maitland-Van Der Zee A. H., Dikkers F. G., Van Drunen C. M. Influence of the gut and airway microbiome on asthma development and disease. Pediatr. Allergy. Immunol. 2024;35(3):e14095. https://doi.org/10.1111/pai.14095
4. Barcik W., Boutin R. C. T., Sokolowska M., Finlay B. B. The role of lung and gut microbiota in the pathology of asthma. Immunity. 2020;52(2):241-255. https://doi.org/10.1016/j.immuni.2020.01.007
5. Xue S., Abdullahi R., Wu N., Zheng J., Su M., Xu M. Gut microecological regulation on bronchiolitis and asthma in children: A review. Clin. Respir. J. 2023;17(10):975-985. https://doi.org/10.1111/crj.13622
6. Azad M. B., Kozyrskyj A. L. Perinatal programming of asthma: the role of gut microbiota. Clin. Dev. Immunol. 2012;2012:932072. https://doi.org/10.1155/2012/932072
7. Gao Y., Nanan R., Macia L., Tan J., Sominsky L. [et al.]. The maternal gut microbiome during pregnancy and offspring allergy and asthma. J. Allergy Clin. Immunol. 2021;148(3):669-678. https://doi.org/10.1016/j.jaci.2021.07.011
8. Demirci M., Tokman H. B., Uysal H. K., Demiryas S., Karakullukcu A. [et al.]. Reduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma. Allergol. Immunopathol. (Madr). 2019;47(4):365-371. https://doi.org/10.1016/j.aller.2018.12.009
9. Pu Q., Lin P., Gao P., Wang Z., Guo K. [et al.]. Gut microbiota regulate gut-lung axis inflammatory responses by mediating ILC2 compartmental migration. J. Immunol. 2021;207(1):257-267. https://doi.org/10.4049/jimmunol.2001304
10. Kanj A. N., Kottom T. J., Schaefbauer K. J., Choudhury M., Limper A. H., Skalski J. H. Dysbiosis of the intestinal fungal microbiota increases lung resident group 2 innate lymphoid cells and is associated with enhanced asthma severity in mice and humans. Respir. Res. 2023;24(1):144. https://doi.org/10.1186/s12931-023-02422-5
11. Akagawa S., Kaneko K. Gut microbiota and allergic diseases in children. Allergol. Int. 2022;71(3):301-309. https://doi.org/10.1016/j.alit.2022.02.004
12. Żółkiewicz J., Marzec A., Ruszczyński M., Feleszko W. Postbiotics-a step beyond pre- and probiotics. Nutrients. 2020;12(8):2189. https://doi.org/10.3390/nu12082189
13. Zakharova I. N., Sugian N. G., Orobinskaya Y. V. Development of the infant’s microbiota depending on the nature of feeding: A review. Pediatriya. Consilium Medicum. – Pediatrics. Consilium Medicum. 2024;(2):106-111. (In Russ.). https://doi.org/10.26442/26586630.2024.2.202939
14. Joseph C. L., Sitarik A. R., Kim H., Huffnagle G., Fujimura K. [et al.]. Infant gut bacterial community composition and food-related manifestation of atopy in early childhood. Pediatr. Allergy Immunol. 2022;33(1):e13704. https://doi.org/10.1111/pai.13704
15. Bannier M. A. G. E., van Best N., Bervoets L., Savelkoul P. H. M., Hornef M. W. [et al.]. Gut microbiota in wheezing preschool children and the association with childhood asthma. Allergy. 2020;75(6):1473-1476. https://doi.org/10.1111/all.14156
16. Suárez-Martínez C., Santaella-Pascual M., Yagüe-Guirao G., García-Marcos L., Ros G., Martínez-Graciá C. The early appearance of asthma and its relationship with gut microbiota: a narrative review. Microorganisms. 2024;12(7):1471. https://doi.org/10.3390/microorganisms12071471
17. Al Bataineh M. T., Hamoudi R. A., Dash N. R., Ramakrishnan R. K., Almasalmeh M. A. [et al.]. Altered respiratory microbiota composition and functionality associated with asthma early in life. BMC Infect. Dis. 2020;20(1):697. https://doi.org/10.1186/s12879-020-05427-3
18. Depner M., Taft D. H., Kirjavainen P. V., Kalanetra K. M., Karvonen A. M. [et al.]. Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma. Nat. Med. 2020;26(11):1766-1775. https://doi.org/10.1038/s41591-020-1095-x
19. Galazzo G., van Best N., Bervoets L., Dapaah I. O., Savelkoul P. H. [et al.]. Development of the microbiota and associations with birth mode, diet, and atopic disorders in a longitudinal analysis of stool samples, collected from infancy through early childhood. Gastroenterology. 2020;158(6):1584-1596. https://doi.org/10.1053/j.gastro.2020.01.024
20. Stokholm J., Blaser M. J., Thorsen J., Rasmussen M. A., Waage J. [et al.]. Maturation of the gut microbiome and risk of asthma in childhood. Nat. Commun. 2018;9(1):141. https://doi.org/10.1038/s41467-017-02573-2
21. Abrahamsson T. R., Wu R. Y., Jenmalm M. C. Gut microbiota and allergy: the importance of the pregnancy period. Pediatr. Res. 2015;77(1-2):214-219. https://doi.org/10.1038/pr.2014.165
22. Arrieta M. C., Stiemsma L. T., Dimitriu P. A., Thorson L., Russell S. [et al.]. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci. Transl. Med. 2015;7(307):307ra152. https://doi.org/10.1126/scitranslmed.aab2271
23. Chen X., Yong S. B., Yii C. Y., Feng B., Hsieh K. S., Li Q. Intestinal microbiota and probiotic intervention in children with bronchial asthma. Heliyon. 2024;10(15):e34916. https://doi.org/10.1016/j.heliyon.2024.e34916
24. Begley L., Madapoosi S., Opron K., Ndum O., Baptist A. [et al.]. Gut microbiota relationships to lung function and adult asthma phenotype: a pilot study. BMJ Open Respir. Res. 2018;5(1):e000324. https://doi.org/10.1136/bmjresp-2018-000324
25. Thorsen J., Rasmussen M. A., Waage J., Mortensen M., Brejnrod A. [et al.]. Infant airway microbiota and topical immune perturbations in the origins of childhood asthma. Nat. Commun. 2019;10(1):5001. https://doi.org/10.1038/s41467-019-12989-7
26. Toivonen L., Karppinen S., Schuez-Havupalo L., Waris M., He Q. [et al.]. Longitudinal changes in early nasal microbiota and the risk of childhood asthma. Pediatrics. 2020;146(4):e20200421. https://doi.org/10.1542/peds.2020-0421
27. Tang H. H. F., Lang A., Teo S. M., Judd L. M., Gangnon R. [et al.]. Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk. J. Allergy Clin. Immunol. 2021;147(5):1683-1691. https://doi.org/10.1016/j.jaci.2020.10.009
28. Mansbach J. M., Luna P. N., Shaw C. A., Hasegawa K., Petrosino J. F. [et al.]. Increased Moraxella and Streptococcus species abundance after severe bronchiolitis is associated with recurrent wheezing. J. Allergy Clin. Immunol. 2020;145(2):518-527.e8. https://doi.org/10.1016/j.jaci.2019.10.034
29. Powell E. A., Fontanella S., Boakes E., Belgrave D., Shaw A. G. [et al.]. Temporal association of the development of oropharyngeal microbiota with early life wheeze in a population-based birth cohort. EBioMedicine. 2019;46:486-498. https://doi.org/10.1016/j.ebiom.2019.07.034
30. Hou J., Song Y., Leung A. S. Y., Tang M. F., Shi M. [et al.]. Temporal dynamics of the nasopharyngeal microbiome and its relationship with childhood asthma exacerbation. Microbiol. Spectr. 2022;10(3):e0012922. https://doi.org/10.1128/spectrum.00129-22
31. Liu T., Lin C. H., Chen Y. L., Jeng S. L., Tsai H. J. [et al.]. Nasal microbiome change during and after exacerbation in asthmatic children. Front. Microbiol. 2022;12:833726. https://doi.org/10.3389/fmicb.2021.833726
32. Chun Y., Do A., Grishina G., Grishin A., Fang G. [et al.]. Integrative study of the upper and lower airway microbiome and transcriptome in asthma. JCI Insight. 2020;5(5):e133707. https://doi.org/10.1172/jci.insight.133707
33. Kim Y. H., Jang H., Kim S. Y., Jung J. H., Kim G. E. [et al.]. Gram-negative microbiota is related to acute exacerbation in children with asthma. Clin. Transl. Allergy. 2021;11(8):e12069. https://doi.org/10.1002/clt2.12069
34. Goldman D. L., Chen Z., Shankar V., Tyberg M., Vicencio A., Burk R. Lower airway microbiota and mycobiota in children with severe asthma. J. Allergy Clin. Immunol. 2018;141(2):808-811.e7. https://doi.org/10.1016/j.jaci.2017.09.018
35. Losol P., Park H. S., Song W. J., Hwang Y. K., Kim S. H. [et al.]. Association of upper airway bacterial microbiota and asthma: systematic review. Asia. Pac. Allergy. 2022;12(3):e32. https://doi.org/10.5415/apallergy.2022.12.e32
36. Huang Y. J., Porsche C., Kozik A. J., Lynch S. V. Microbiome-immune interactions in allergy and asthma. J. Allergy Clin. Immunol. Pract. 2022;10(9):2244-2251. https://doi.org/10.1016/j.jaip.2022.05.038
37. Ver Heul A., Planer J., Kau A. L. The human microbiota and asthma. Clin. Rev. Allergy Immunol. 2019;57(3):350-363. https://doi.org/10.1007/s12016-018-8719-7
38. Chung K. F. Airway microbial dysbiosis in asthmatic patients: A target for prevention and treatment? J. Allergy Clin. Immunol. 2017;139(4):1071-1081. https://doi.org/10.1016/j.jaci.2017.02.004
39. Abdel-Aziz M. I., Brinkman P., Vijverberg S. J. H., Neerincx A. H., Riley J. H. [et al.]. Sputum microbiome profiles identify severe asthma phenotypes of relative stability at 12 to 18 months. J. Allergy Clin. Immunol. 2021;147(1):123-134. https://doi.org/10.1016/j.jaci.2020.04.018
40. Valverde-Molina J., García-Marcos L. Microbiome and asthma: microbial dysbiosis and the origins, phenotypes, persistence, and severity of asthma. Nutrients. 2023;15(3):486. https://doi.org/10.3390/nu15030486
41. Mannion J. M., McLoughlin R. M., Lalor S. J. The airway microbiome-IL-17 axis: a critical regulator of chronic inflammatory disease. Clin. Rev. Allergy Immunol. 2023;64(2):161-178. https://doi.org/10.1007/s12016-022-08928-y
42. Hu M., Zhao X., Liu Y., Zhou H., You Y., Xue Z. Complex interplay of gut microbiota between obesity and asthma in children. Front. Microbiol. 2023;14:1264356. https://doi.org/10.3389/fmicb.2023.1264356
43. Han X., Zhu Z., Xiao Q., Li J., Hong X. [et al.]. Obesity-related biomarkers underlie a shared genetic architecture between childhood body mass index and childhood asthma. Commun. Biol. 2022;5(1):1098. https://doi.org/10.1038/s42003-022-04070-9
44. Dolbnya S. V., Tolkunova A. A., Ponamareva V. R., Klimov L. Ya., Barycheva L. Yu. [et al.]. Immune and nonimmune mechanisms behind the interaction between bronchial asthma and obesity in children: a modern perspective. Medical News of North Caucasus. 2025;20(2):190-197. https://doi.org/10.14300/mnnc.2025.20044
45. Zakharova I. N., Dolbnya S. V., Kuryaninova V. A., Klimov L. Ya., Kipkeev Sh. O. [et al.]. Role of vitamin D in pre-school children’s health. Meditsinskiy sovet. – Medical Council. 2021;(1):37-48. (In Russ.). https://doi.org/10.21518/2079-701X-2021-1-37-48
46. Love P., Laws R., Litterbach E., Campbell K. J. Factors influencing parental engagement in an early childhood obesity prevention program implemented at scale: the infant program. Nutrients. 2018;10(4):509. https://doi.org/10.3390/nu10040509
47. Kondratyeva E. I., Loshkova E. V., Ilenkova N. A., Mizernitskiy Yu. L., Klimov L.Ya. [et al.]. The role of the VDR gene in the formation of clinical manifestations, complications and response to therapy in bronchial asthma. Vopr. prakt. pediatr. – Clinical Practice in Pediatrics. 2023;18(1):43-54. (In Russ.). https://doi.org/10.20953/1817-7646-2023-1-43-54
48. Jolliffe D. A., Camargo C. A. Jr., Sluyter J. D., Aglipay M., Aloia J. F., Ganmaa D. Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials. Lancet Diabetes Endocrinol. 2021;9(5):276-292. https://doi.org/10.1016/S2213-8587(21)00051-6
49. Visser E., Ten Brinke A., Sizoo D., Pepels J. J. S., Ten Have L. [et al.]. Effect of dietary interventions on markers of type 2 inflammation in asthma: A systematic review. Respir. Med. 2024;221:107504. https://doi.org/10.1016/j.rmed.2023.107504
50. Vlieg-Boerstra B., de Jong N., Meyer R., Agostoni C., De Cosmi V. [et al.]. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis. Allergy. 2022;77(5):1373-1388. https://doi.org/10.1111/all.15136
51. Drall K. M., Field C. J., Haqq A. M., de Souza R. J., Tun H. M. [et al.]. Vitamin D supplementation in pregnancy and early infancy in relation to gut microbiota composition and C. difficile colonization: implications for viral respiratory infections. Gut Microbes. 2020;12(1):1799734. https://doi.org/10.1080/19490976.2020.1799734
52. Kassem Z., Sitarik A., Levin A. M., Lynch S. V., Havstad S. [et al.]. Maternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study. Matern. Health Neonatol. Perinatol. 2020;6:5. https://doi.org/10.1186/s40748-020-00119-x
53. Aparicio A., Gold D. R., Weiss S. T., Litonjua A. A., Lee-Sarwar K., Liu Y. Y. Association of vitamin d level and maternal gut microbiome during pregnancy: findings from a randomized controlled trial of antenatal vitamin D supplementation. Nutrients. 2023;15(9):2059. https://doi.org/10.3390/nu15092059
54. Lee-Sarwar K. A., Chen Y. C., Chen Y. Y., Kozyrskyj A. L., Mandhane P. J. [et al.]. The maternal prenatal and offspring early-life gut microbiome of childhood asthma phenotypes. Allergy. 2023;78(2):418-428. https://doi.org/10.1111/all.15516
55. Casali L., Stella G. M. The microbiota in children and adolescents with asthma. Children (Basel). 2024;11(10):1175. https://doi.org/10.3390/children11101175
56. Gorelov A. V., Zakharova I. N., Khavkin A. I., Kafarskaya L. I., Usenko D. V. [et al.]. Resolution of the Council of Experts «Dysbiosis. Immediate and long-term consequences of microbiome disorders and options for their correction with probiotics». Vopr. prakt. pediatr. – Clinical Practice in Pediatrics. 2022;17(1):213-221. (In Russ.). https://doi.org/10.20953/1817-7646-2022-1-213-221
57. Zakharova I. N., Gorelov A. V., Osmanov I. M., Khavkin A. I., Usenko D. V. [et al.]. Resolution on the results of the Expert Council on the topic «Antibiotics, microbiota and probiotics: Strategies for the prevention of antibiotic-associated syndrome and antibiotic resistance in pediatrics». Meditsinskiy sovet. – Medical Council. 2025;(11):10-17. (In Russ.). https://doi.org/10.21518/ms2025-224
58. Huang C. F., Chie W. C., Wang I. J. Efficacy of lactobacillus administration in school-age children with asthma: a randomized, placebo-controlled trial. Nutrients. 2018;10(11):1678. https://doi.org/10.3390/nu10111678
59. Li L., Fang Z., Lee Y. K., Zhao J., Zhang H. [et al.]. Efficacy and safety of lactobacillus reuteri CCFM1040 in allergic rhinitis and asthma: a randomized, placebo-controlled trial. Front. Nutr. 2022;9:862934. https://doi.org/10.3389/fnut.2022.862934
60. Drago L., Cioffi L., Giuliano M., Pane M., Amoruso A. [et al.]. The probiotics in pediatric asthma management (PROPAM) study in the primary care setting: a randomized, controlled, double-blind trial with Ligilactobacillus salivarius LS01 (DSM 22775) and Bifidobacterium breve B632 (DSM 24706). J. Immunol. Res. 2022;2022:3837418. https://doi.org/10.1155/2022/3837418

Keywords: intestinal microbiota, bronchial asthma, children, microbiota, vitamin D