• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2025.20075

Application of niosomic form of succinic acid for activation of cellular respiration in adipocytes

[Experimental medicine]
Anna Khodzhayan; Igor Bazikov; Alexander Maltsev; Margarita Gevandova; Anna Efremenko;

The effect of the niosomal form of succinic acid on the activation of cellular respiration in adipocytes for the prevention of obesity was investigated. Obesity simulations were performed on high calorie diet rabbits dosed with 2 ml of niosomal succinicacid for 5 days in adipose tissue. The dynamics of the live weight of experimental animals, the correlation of changes in the content of glucose, cholesterol, triglycerides and lipoproteins in the blood plasma of rabbits, as well as changes in the pro-antioxidant balance in adipose tissue were studied. Reduction of blood glucose, triglycerides, cholesterol, low-density lipoproteins and normalization of lipid metabolism has been demonstrated. These effects with the introduction of the niosomal form of succinic acid are due to the activation of mitochondrial respiration, glucose metabolism in the Кrebs cycle, ATP formation, activation of free radical processes and antioxidant protection.

Download

References:
1. GBD 2021 Risk Factor Collaborators. Global burden of 88 risk factors in 204 countries and territories, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024;403(10440):2162-2203. https://doi.org/10.1016/S0140-6736(24)00933-4
2. GBD 2021 Adult BMI Collaborators. Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021. Lancet. 2025;405(10481):813-838. https://doi.org/10.1016/S0140-6736(25)00355-1
3. Drapkina O. M., Shalnova S. A., Imaeva A. E., Balanova Yu. A. [et al.]. Epidemiology of cardiovascular diseases in regions of Russian Federation. Third survey (ESSE-RF-3). Rationale and study design. Kardiovaskulyarnayaterapiya i profilaktika. – Cardiovascular Therapy and Prevention. 2022;21(5):3246. (In Russ.). https://doi.org/10.15829/1728-8800-2022-3246
4. Kulkarni A., Kulkarni A. S., Gubbi S., Barzilai N. Benefits of Metformin in attenuating the hallmarks of Aging. Cell. Metabol. 2020. https://doi.org/10.1016/j.cmet.2020.04.001
5. Fernández-Veledo S., Ceperuelo-Mallafré V., Vendrell J. Rethinking succinate: An unexpected hormone-like metabolite in energy homeostasis. Trends Endocrinol. Metab. 2021;32:680-692. https://doi.org/10.1016/j.tem.2021.06.003
6. Liao F., Yao C., Chen S., Wu T., Lin S. Y. Transdermal Delivery of Succinate Accelerates Energy Dissipation of Brown Adipocytes to Reduce Remote Fat Accumulation. Mol. Pharm. 2022;19:4299-4310. https://doi.org/10.1021/acs.molpharmaceut.2c00628
7. Stephen J., Kendall S. Z., Cheyanne S., Daniela E., Caty Sh. [et al.]. The effect of succinic acid on the metabolic profile in high-fat dietinduced obesity and insulin resistance. Physiol. Rep. 2020;8(21):e14630. https://doi.org/10.14814/phy2.14630
8. Makarova M., Makarov V. Diet-Induced models of metabolic disturbances. Report 2: Experimental obesity. Laboratornyye zhivotnyye dlya nauchnykh issledovaniy. – Laboratory Animals for Science. 2018;2. (In Russ.). https://doi.org/10.29296/2618723X-2018-02-05
9. Gavrilenko M. M., Volgina T. N., Saranchina N. V., Gavrilenko M. A. Method of determining of malondialdehyde. Patent RU 2797016 C1. publ. 30.05.2023. (In Russ.).
10. Smirnova L. P., Kondakova I. V., Borunov E. V. Method of determining of superoxide dismutase activity. Patent RU 2272074 C1. publ. 20.03.2006 (In Russ.)
11. Order of the Ministry of Health and Social Development of the Russian Federation dated 23.08.2010 N 708N «On Approval of the Rules of Laboratory Practice in the Russian Federation». Available at: https://normativ.kontur.ru/document?moduleId=1&documentId=165691 (In Russ.).
12. Cuomo P., Capparelli R., Iannelli A., Iannelli D. Role of Branched-Chain Amino Acid Metabolism in Type 2 Diabetes, Obesity, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease. Int. J. Mol. Sci. 2022;23:4325. https://doi.org/10.3390/ijms23084325
13. Huang J., Fraser M. E. The structure of succinyl-CoAsynthetase bound to the succinyl-phosphate intermediate clarifies the catalytic mechanism of ATP-citrate lyase. Acta Crystallogr. F Struct. Biol. Commun. 2022;78:363-370. https://doi.org/10.1107/S2053230X22008810
14. Zhang S., Liang Y., Li L., Chen Y., Wu P. [et al.]. Succinate: A Novel Mediator to Promote Atherosclerotic Lesion Progression. DNA Cell. Biol. 2022;41:285-291. https://doi.org/10.1089/dna.2021.0345
15. Liu X., Chen Y., Zhao L., Tian Q., de Avila J. M. [et al.]. Dietary succinate supplementation to maternal mice improves fetal brown adipose tissue development and thermogenesis of female offspring. J. Nutr. Biochem. 2022;100:108908. https://doi.org/10.1016/j.jnutbio.2021.108908
16. Morigny P., Boucher J., Arner P., Langin D. Lipid and glucose metabolism in white adipocytes: Pathways, dysfunction and therapeutics. Nat. Rev. Endocrinol. 2021;17:276-295. https://doi.org/10.1038/s41574-021-00471-8
17. Mills E. L., Pierce K. A., Jedrychowski M. P., Garrity R., Winther S. [et al.]. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature. 2018;560:102-106.
https://doi.org/10.1038/s41586-018-0353-2
18. Chen H., Jin C., Xie L., Wu J. Succinate as a signaling molecule in the mediation of liver diseases. Biochim. Biophys. Acta Mol. Basis Dis. 2024;1870:166935. https://doi.org/10.1016/j.bbadis.2023.166935
19. Atallah R., Gindlhuber J., Heinemann A. Succinate in innate immunity: linking metabolic reprogramming to immune modulation. Front. Immunol. 2025;16:1661948. https://doi.org/10.3389/fimmu.2025.1661948
20. Keiran N., Ceperuelo-Mallafré V., Calvo E., Hernández- Alvarez M. I., Ejarque M. [et al.]. SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity. Nat. Immunol. 2019;20:581-592. https://doi.org/10.1038/s41590-019-0372-7
21. Morigny P., Boucher J., Arner P., Langin D. Lipid and glucose metabolism in white adipocytes: Pathways, dysfunction and therapeutics. Nat. Rev. Endocrinol. 2021;17:276-295. https://doi.org/10.1038/s41574-021-00471-8

Keywords: obesity, succinic acid, niosomes