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EBSCO

https://doi.org/10.14300/mnnc.2025.20074

Changes in growth parameters of conditionally pathogenic microorganisms under the influence of nisin

[Experimental medicine]
Danil Stanislavovich Panteleev; Oksana Alexandrovna Shulyatnikova; Anatoliy Godovalov; Gennady Ivanovich Rogozhnikov; Mikhail Vladimirovich Yakovlev;

The study investigated the effect of nisin on growth parameters and the biofilm formed by Staphylococcus aureus ATCC 25923 and Escherichia coli M-17 strains. The weak activity of nisin relative to E. coli strains has been demonstrated. Nizin disrupted the integrity of bacterial cell membranes, leading to their death, and disrupts the formation of biofilms. Nizin is a promising drug for the development of antimicrobial drugs and the prevention of biofilm formation, including on dentures.

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Keywords: biofilm, oral cavity, periodontium, oral microflora, dentures, bacteriocins, nisin