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https://doi.org/10.14300/mnnc.2025.20073

Short cationic peptide with antibacterial activity identified in the proteome of Blautia product

[Clinical Pharmacology] [Pharmacology]
Albert Bolatchiev; Vladimir Baturin; Albert Ashotovich Vartanyan; Elizaveta Yuryevna Bolatchieva; Nikolay Didenko; Aleksandrovich Veretennikov Taras;

Using the peptide mining method, for the first time, we identified a short cationic peptide ABP9L (consisting of 9 amino acid residues) in the proteome of the bacterium Blautia producta (a component of the human microbiome). ABP9 had antibacterial activity against a number of Gram-positive and Gram-negative bacteria and was effective in vivo in an experimental model of generalized infection (Pseudomonas aeruginosa) in mice. In addition, the studied compound did not have hemolytic activity and cytotoxic effect in vitro.

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Keywords: antibiotic resistance, antimicrobial peptide, drug discovery, de novo peptide development