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https://doi.org/10.14300/mnnc.2025.20044

Immune and non-immune mechanisms behind the interaction between bronchial asthma and obesity in children: a modern perspective

[Reviews]
Svetlana Dolbnya; Anna Aleksandrovna Tolkunova; Viktoriya Romanovna Ponamareva; Leonid Klimov; Lyudmila Barycheva; Roza Atanesyan; Vera Valentinovna Kuznetsova; Natalia Fedko;

Currently, bronchial asthma (BA) and obesity are two of the most significant chronic diseases among children and adolescents worldwide. The relationship between these pathological conditions in childhood is complex, as it is influenced by numerous modifying factors such as gender, degree of obesity, presence of atopy, insulin resistance, and dyslipidemia. This review presents current data regarding the subtype «obesity-associated asthma», in which obesity increases the risk of developing asthma or exacerbates its course in children and adolescents.

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Keywords: obesity, bronchial asthma, children, metabolic programming, microbiota, vitamin D