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https://doi.org/10.14300/mnnc.2025.20017

The role of epigenetic modifications in the arterial hypertension pathogenesis: focus on DNA methylation

[Reviews]
Kubanich Aitbaev; Ilhom Murkamilov; Viktor Fomin; Furkat Yusupov;

Arterial hypertension (herein after referred to as hypertension) is a complex disease resulting through an interplay of genetic, epigenetic, and environmental factors. Research shows that genetic factors contribute to 30–50 % of the hypertension variations, while epigenetic markers or modifications play a significant role, too, which is by influencing gene expression and promoting hypertension development. This review focuses on the role of DNA methylation – one of the most stable epigenetic mechanisms – in the development of hypertension. We also explore here the potential of using DNA methylation as an objective marker employed to identify hypertension, which is not affected by short-term factors such as stress or recently experienced physical activity.

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Keywords: epigenetics, arterial hypertension, epigenetic modifications, DNA methylation, epigenetic markers