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A modern model of the pathogenesis of gastroesophageal reflux disease in patients with comorbidity of obesity and diabetes mellitus type 2

[Internal diseases]
Elena Andreeva; Vladimir Baturin; Zuriana Musovna Campuyeva;

The results of a study determining the effect of obesity on the course of GERD in patients with type 2 diabetes mellitus and without impaired carbohydrate metabolism are presented. By the method of multiple regression analysis the dependence between the parameters of daily esophageal pH-metry and indicators of carbohydrate metabolism (venous plasma glucose, insulin resistance index – HOMA, glycated hemoglobin – HbA1c), and markers of adipose tissue inflammation (TNF-α, IL-6, leptin) was determined.

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Keywords: obesity, GERD, diabetes mellitus, 24-hour esophageal pH-metry


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