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https://doi.org/10.14300/mnnc.2025.20003

Genetic risk groups for celiac disease in the children’s population of Stavropol Territory

[Pediatrics]
Elizaveta Andreevna Cherkasova; Victoria Kuryaninova; Leonid Klimov; Tatyana Andreevna Ivenskaya; Liana Lenorovna Sheitanidi; Vyacheslav Kashnikov; Svetlana Kashnikova; Violetta Vladimirovna Kulish;

At present, sufficient data have been accumulated to state that celiac disease is a genetically determined disease associated with antigens of the human major histocompatibility complex (HLA-DQ2, HLA-DQ8 and HLA-DQ7). The combination of alleles in various variants determines the genetically determined risk of development and manifestation of celiac disease in each particular patient. It was revealed that in the genetic structure of celiac disease in the pediatric population of the Stavropol Territory, a combination of alleles that determine a high and significant genetic risk of disease manifestation prevails. As the degree of genetic risk of celiac disease manifestation decreases, a decrease in the level of disease-specific antibodies, a decrease in the proportion of patients with a total degree of villous atrophy of the small intestine and an increase in the proportion of patients with a moderate degree of atrophic changes in the small intestine are noted.

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Keywords: celiac disease, major histocompatibility complex, HLA-DQ2, HLA-DQ8, HLA-DQ7 molecules, genetic risk of celiac disease development