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https://doi.org/10.14300/mnnc.2024.19071

Cationic peptide PEP-36E is effective against carbapenem-resistant gram-negative bacteria in vitro and in vivo

[Experimental medicine]
Albert Bolatchiev; Vladimir Baturin; Ирина Ивановна Olshanskaya; Albert Ashotovich Vartanyan; Elizaveta Yuryevna Bolatchieva; Nikolay Didenko; Darina Muratovna Kumukova; Evgeny Eduardovich Beknazarov;

Antibiotic resistance causes 1.2 million direct and 4.95 million associated deaths annually. Classic small molecule antibiotics are not attractive from an investment point of view for pharmaceutical companies due to the rapid development of resistance. Antimicrobial peptides (AMPs) have pronounced antibacterial activity with a significantly lower probability of developing resistance. Various machine learning methods can be used for de novo development of new AMPs. Previously, we developed a short cationic AMP PEP-36E. In the course of the work, it was shown that PEP-36E is active in vitro against Gram-negative bacteria resistant to carbapenems. Moreover, PEP-36E at an empirical dose of 100 μg/mouse reduced mortality in both models of generalized infection caused by Klebsiella pneumoniae and Acinetobacter baumannii.

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References:
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Keywords: antimicrobial peptides, antibiotic resistance